PXD049452
PXD049452 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic characterization of the myocardium in canines subjected to left bundle branch area pacing |
| Description | Left bundle branch area pacing (LBBAP) has shown effectiveness in dyssynchronous heart failure (DHF) and can be categorized into two types: left bundle branch pacing (LBBP) and left ventricular septal pacing (LVSP). However, the basic mechanisms are unknown. Here, we performed proteomic profiling of the myocardium from 3 control, 3 DHF, 2 LBBP and 2 LVSP canines. Subsequently, targeted proteomics were employed to further validate several biomarkers in 6 control, 6 DHF, 6 LBBP and 6 LVSP canines. This study revealed that LBBP reversed the expression of proteins associated with contraction process, while LVSP reversed expression of proteins associated with adhesion process. This study provides new insights into mechanisms behind the superior outcomes of LBBP. |
| HostingRepository | iProX |
| AnnounceDate | 2024-02-20 |
| AnnouncementXML | Submission_2025-01-01_19:32:28.685.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sijing Cheng |
| SpeciesList | scientific name: Canis lupus familiaris; NCBI TaxID: 9615; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-02-17 22:23:10 | ID requested | |
| ⏵ 1 | 2025-01-01 19:32:29 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: myocardium, proteomics, canine, left bundle branch area pacing |
Contact List
| Wei Hua | |
|---|---|
| contact affiliation | State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College |
| contact email | drhuawei@fuwai.com |
| lab head | |
| Sijing Cheng | |
| contact affiliation | State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College |
| contact email | sijing_cheng@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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