PXD049439

PXD049439 is an original dataset announced via ProteomeXchange.

Title	Fkbp5 Gene Deletion: Impacts on Circadian Rhythmicity and Brain Proteomics in Aged Mice
Description	FKBP51, also known as FK506-binding protein 51, is a molecular chaperone and scaffolding protein with significant roles in regulating hormone signaling and stress responding. Genetic variants in FKBP5, which encodes FKBP51, have been implicated in a growing number of neuropsychiatric disorders, which has spurred efforts to target FKBP51 therapeutically. However, the molecular mechanisms by which FKBP51 influences the pathways affected in these disorders are not fully understood. Protein changes in Fkbp5 KO mice, as measured by histology and proteomics, revealed alterations in a brain region- and sex-dependent manner.
HostingRepository	PRIDE
AnnounceDate	2024-09-05
AnnouncementXML	Submission_2024-09-05_13:18:02.781.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stanley Stevens
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-17 02:12:07	ID requested
⏵ 1	2024-09-05 13:18:03	announced

Gebru NT, Guergues J, Verdina LA, Wohlfahrt J, Wang S, Armendariz DS, Gray M, Beaulieu-Abdelahad D, Stevens SM, Gulick D, Blair LJ, Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics in aged mice. Aging Cell, ():e14314(2024) [pubmed]

10.1111/acel.14314;

submitter keyword: knock out, brain, hippocampus, DIA, KO, PRM, aged, amygdala, mouse,Fkbp5

Stanley Stevens
contact affiliation	University of South Florida, USA
contact email	smstevens@usf.edu
lab head
Stanley Stevens
contact affiliation	University of South Florida
contact email	smstevens@usf.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD049439

PRIDE project URI

• PRIDE
  1. PXD049439
     1. Label: PRIDE project
     2. Name: Fkbp5 Gene Deletion: Impacts on Circadian Rhythmicity and Brain Proteomics in Aged Mice