PXD049430 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic and Metabolomic Profile of Cognitive Stability and Decline Over an Aerobic Exercise Intervention and 5-years later in Older Adults |
Description | . In this study we identify a unique signature protein and metabolic biomarker panel for those who improve in cognition and those who decline, assessed by the Montreal Cognitive Assessment (MoCA). We investigate a discovery cohort of Brain in Motion participants involving a quasi-experimental aerobic exercise intervention study and analyze blood plasma before and after a six-month aerobic exercise intervention and 5 years later. We relate the differentially expressed proteins and metabolites to subjective sleep quality measures and fitness level. This study informs on the differences in the plasma of those who decline and those who improve in cognition, identifying pathways that are of importance for preventing cognitive decline. |
HostingRepository | PRIDE |
AnnounceDate | 2025-04-15 |
AnnouncementXML | Submission_2025-04-15_11:02:21.959.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Luiz Gustavo de Almeida |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-02-16 11:47:36 | ID requested | |
⏵ 1 | 2025-04-15 11:02:22 | announced | |
Publication List
10.1002/ana.27210; |
Donald AMH, de Almeida LGN, Dabaja MZ, Orchard I, Ybema K, Tsegai V, Armstrong V, Smith S, Young D, Longman RS, Tyndall AV, Rawling JM, Hill MD, Tsai WH, Agbani E, Poulin MJ, Dufour A, Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention. Ann Neurol, 97(5):1007-1018(2025) [pubmed] |
Keyword List
submitter keyword: Plasma, Metabolomics, Exercise, Aging, Proteomics |
Contact List
Antoine Dufour |
contact affiliation | Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada; The Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada |
contact email | antoine.dufour@ucalgary.ca |
lab head | |
Luiz Gustavo de Almeida |
contact affiliation | University of Calgary |
contact email | luizgustavo.biotec@hotmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD049430
- Label: PRIDE project
- Name: Proteomic and Metabolomic Profile of Cognitive Stability and Decline Over an Aerobic Exercise Intervention and 5-years later in Older Adults