PXD049423

PXD049423 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mechanism of αKtx12 peptide on hippocampus
Description	Voltage-gated potassium (Kv) channels, integral to cellular repolarization, are potential therapeutic targets in neuroinflammatory disorders and neurodegenerative diseases. The Kv1.3 channel, pivotal in microglial activation and striatal cholinergic interneurons (SCINs) excitability, has garnered attention. This study explores oneTityus bahiensis scorpion venom peptide, identified as αKtx12 a potent inhibitor of Kv1.3, Kv1.2, and Shaker subtypes. In SH-SY5Y cells, αKtx12 significantly enhances viability, validating its pharmacological potential. Animal models elucidate αKtx12's CNS mechanism. Neuroproteomic analyses highlight αKtx12 as a valuable tool for characterizing neuroplasticity and neurotrophism, revealing its ability to elicit more physiological responses than mere electrical impediments. The peptide's potential to promote cellular proliferation and neuroprotection suggests a role in functional recovery from nervous system injury or disease.
HostingRepository	jPOST
AnnounceDate	2024-02-16
AnnouncementXML	Submission_2024-02-16_05:13:37.812.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Emidio Beraldo Neto
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116; scientific name: Tityus bahiensis; NCBI TaxID: 50343;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrument	instrument; LCMS-IT-TOF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-16 05:08:26	ID requested
⏵ 1	2024-02-16 05:13:38	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Voltage-gated potassium channel, neurotoxin, hippocampus, scorpion toxin, Kv1.3, αKtx12, peptide

submitter keyword: Voltage-gated potassium channel, neurotoxin, hippocampus, scorpion toxin, Kv1.3, αKtx12, peptide

Contact List

Emidio Beraldo Neto
lab head
Emidio Beraldo Neto
contact affiliation	Butantan Institute
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002939/