PXD049384 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | PRR of Tau Crosslinking with Tubulin |
| Description | We used cross-linking mass spectrometry with the cleavable cross-linker, disuccinimidyl dibutyric urea (DSBU) to map sites of interaction between the proline rich domain (PRR, tau amino acids 149-244) and tubulin. For comparison, we also conducted these experiments with PRR constructs containing multiple phosphomimic mutations (from serine or threonine to glutamate) at tau amino acid positions 181, 217, 231 and 235. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-09 |
| AnnouncementXML | Submission_2026-03-08_18:10:05.619.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hee Jong Kim |
| SpeciesList | scientific name: Escherichia coli; NCBI TaxID: NEWT:562; scientific name: Bos taurus (Bovine); NCBI TaxID: NEWT:9913; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-02-14 09:23:09 | ID requested | |
| ⏵ 1 | 2026-03-08 18:10:06 | announced | |
Publication List
| Acosta K, Brue CR, Holubovska P, Kim HJ, Mayne L, Murakami K, Rhoades E, Structural insights into the role of the proline rich region in tau function. Structure, 33(3):465-474.e8(2025) [pubmed] |
| 10.1016/j.str.2024.12.017; |
Keyword List
| submitter keyword: tubulin,Tau, phosphorylation, proline rich region |
Contact List
| Kenji Murakami |
|---|
| contact affiliation | University of Pennsylvania, School of Medicine |
| contact email | kenjim@pennmedicine.upenn.edu |
| lab head | |
| Hee Jong Kim |
|---|
| contact affiliation | University of Pennsylvania |
| contact email | heejong@heejong.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD049384 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD049384
- Label: PRIDE project
- Name: PRR of Tau Crosslinking with Tubulin
