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PXD049365

PXD049365 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSRF is a new player in 3D genome organization and stem cell pluripotency
DescriptionSerum response factor (SRF) is a transcription factor essential for cell proliferation, differentiation, and migration, and is required for primitive streak and mesoderm formation in the embryo. The canonical roles of SRF are mediated by a diverse set of context-dependent cofactors. Here we show that SRF physically interacts with CTCF and cohesin subunits at TAD boundaries and loop anchors. SRF reinforces the insulation of TADs and promotes the formation of long-range chromatin loops. In ES cells, SRF associates with Oct4, Sox2, and Nanog and contributes to the formation of 3D pluripotency hubs. Our findings reveal new roles of SRF in higher-order chromatin organization.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_07:01:46.011.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDavid Meierhofer
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-02-14 04:35:51ID requested
12024-10-15 01:50:07announced
22024-10-22 07:01:46announced2024-10-22: Updated project metadata.
Publication List
10.1016/J.CELREP.2024.114846;
Keyword List
submitter keyword: Serum response factor (SRF)
higher-order chromatin organization
Contact List
Bernhard Herrmann
contact affiliationMax-Planck-Institut for Molecular Genetics Department of Developmental Genetics Ihnestraße 63-73 14195 Berlin, Germany
contact emailherrmann@molgen.mpg.de
lab head
David Meierhofer
contact affiliationMass Spectrometry Facility MPIMG
contact emailmeierhof@molgen.mpg.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
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