PXD049364

PXD049364 is an original dataset announced via ProteomeXchange.

Title	Immunoglobulins G from Systemic Sclerosis Patients Modify the Proteome of Endothelial Cells Depending on Antinuclear Antibodies Serotypes
Description	Systemic sclerosis (SSc) is a heterogeneous connective tissue disease characterized by autoimmunity, vasculopathy and excessive fibrosis (1). Antinuclear antibodies (ANA) are strong diagnostic and prognosis biomarkers but their pathogenicity in fibrosis and vasculopathy remains unclear. Functional antibodies (FA) such as angiotensin II type 1 receptor [AT1R] and endothelin-1 type A receptor [ETAR] have been described in SSc and might be implicated in vasculopathy, in which endothelial cells (EC) are key players. We aimed to explore the effect of purified IgG from SSc patients on the proteome of EC and examine the influence of ANA serotypes or FA. The detailed methodology is available in the Supplementary Material section.
HostingRepository	PRIDE
AnnounceDate	2025-03-24
AnnouncementXML	Submission_2025-03-24_08:53:16.393.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	BRAY FABRICE
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-14 04:26:38	ID requested
⏵ 1	2025-03-24 08:53:16	announced

10.1136/RMDOPEN-2024-004290;

submitter keyword: Systemic sclerosis, IgG, endothelial cells, Proteomics, Antinuclear antibodies

Bray fabrice
contact affiliation	MSAP UAR 3290 Bat C4 avenue paul langevin villeneuve d'ascq
contact email	fabrice.bray@univ-lille.fr
lab head
BRAY FABRICE
contact affiliation	MSAP USR 3290
contact email	fabrice.bray@univ-lille.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD049364
     1. Label: PRIDE project
     2. Name: Immunoglobulins G from Systemic Sclerosis Patients Modify the Proteome of Endothelial Cells Depending on Antinuclear Antibodies Serotypes