PXD049326 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Automated high-throughput biological sex identification from archaeological human dental enamel using targeted proteomics |
Description | Biological sex is a key information for archaeological and forensic studies, which can be assessed in enamel using proteomics. However, the lack of a standard approach for fast and accurate sex identification limits the reach of proteomics applications. Here, we introduce a targeted proteomics-based workflow that builds on a rapid, non-destructive, sensitive, and quantitative mass spectrometry (MS) strategy for the determination of biological sex from human dental enamel, including a R-Shiny interface for the data analysis. The method was first developed and optimised using modern teeth material and then validated on an independent set of modern deciduous teeth of known sex. The assay was then applied to archaeological material and demonstrated unprecedented specificity and scalability for molecular sex inference, with the possibility of analysing > 300 individuals in less than two days of MS measurement time, and with subsequent confident sex assignment in less than a day of data analysis. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_06:06:39.780.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Claire Koenig |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-02-12 02:07:40 | ID requested | |
⏵ 1 | 2024-10-17 06:06:40 | announced | |
Publication List
10.1021/acs.jproteome.4c00557; |
Koenig C, Bortel P, Paterson RS, Rendl B, Madupe PP, Troch, é GB, Hermann NV, Mart, í, nez de Pinillos M, Martin, ó, n-Torres M, Mularczyk S, Schjellerup J, ø, rkov ML, Gerner C, Kanz F, Martinez-Val A, Cappellini E, Olsen JV, Automated High-Throughput Biological Sex Identification from Archeological Human Dental Enamel Using Targeted Proteomics. J Proteome Res, ():(2024) [pubmed] |
Keyword List
submitter keyword: Forensics, PRM, Sex,Palaeoproteomics, Archaeology, Enamel |
Contact List
Jesper V. Olsen |
contact affiliation | Novo Nordisk Foundation Center for Protein Research, Proteomics Program, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. |
contact email | jesper.olsen@cpr.ku.dk |
lab head | |
Claire Koenig |
contact affiliation | Novo Nordisk Foundation Center for Protein Research, University of Copenhagen |
contact email | claire.koenig@cpr.ku.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD049326
- Label: PRIDE project
- Name: Automated high-throughput biological sex identification from archaeological human dental enamel using targeted proteomics