PXD049299

PXD049299 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells
Description	In a previous study, we described the biochemical properties of a newly synthesized group of imidazopyrazole compounds. In this paper, to improve our knowledge on the pharmacological properties of these chemical compounds, we carry out a differential proteomic analysis on a hu-man melanoma cell line treated with one of these imidazopyrazole derivatives. The results show the changes to Skmel28 melanoma cell line proteome induced by 24h, 48h and 72h of imidazopy-razole treatment.
HostingRepository	PRIDE
AnnounceDate	2024-06-21
AnnouncementXML	Submission_2024-06-21_07:15:38.908.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gabriela Coronel Vargas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-09 06:01:04	ID requested
⏵ 1	2024-06-21 07:15:39	announced

Publication List

10.3390/IJMS25126760;

10.3390/IJMS25126760;

Keyword List

submitter keyword: imidazopyrazole
cell growth inhibition
differential proteomic analysis
melanoma

submitter keyword: imidazopyrazole

cell growth inhibition

differential proteomic analysis

melanoma

Contact List

Camillo Rosano
contact affiliation	IRCCS Ospedale Policlinico San Martino, Genova, Italy
contact email	camillo.rosano@hsanmartino.it
lab head
Gabriela Coronel Vargas
contact affiliation	University of Genova
contact email	gabrielafernanda.coronelvargas@edu.unige.it
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD049299
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD049299

PRIDE project URI

Repository Record List

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