PXD049296

PXD049296 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis of Tear Fluid from the Offspring of Keratoconus Patients Toward Novel Biomarkers and Pathways Associated with Corneal Biomechanical Weakness and Disease Susceptibility.
Description	Keratoconus (KC) is a chronic and degenerative condition marked by pathological weakening, thinning, and protrusion of the corneal tissue. Corneal biomechanical weakness constitutes a hallmark of early keratoconus (KC) stages, which has underlined the importance of the study of biomechanical response in the early clinical screening of KC. In this line, the family history of KC is consistently identified as the leading risk factor for KC development, and the first-order pediatric relatives of KC patients are considered the most vulnerable population for KC development. On the other hand, tear fluid has become an attractive and accessible source that could be useful in identifying the molecular targets of several ocular diseases, such as corneal ectasias and more specifically KC disease. So, based on the vulnerability of first-order pediatric KC relatives to develop the disease, as well as the potential of tear fluid as a biomarker source, the purpose of this study was to analyze quantitatively and qualitatively the tear proteome of young KC offspring using micro–liquid chromatography coupled to tandem mass spectrometry, trying to get closer to the molecular drivers underlying the alterations in corneal biomechanical properties at at-risk stages of KC and to provide new insights into the molecular mechanisms involved in the earlier stages of the disease.
HostingRepository	PRIDE
AnnounceDate	2025-06-09
AnnouncementXML	Submission_2025-06-08_16:18:58.619.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Susana Bravo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-09 04:35:16	ID requested
⏵ 1	2025-06-08 16:18:59	announced

L, ó, pez-L, ó, pez M, Regueiro U, Bravo S, Pena C, Pastoriza Y, Conde-Amboage M, Hervella P, Lema I, Tear Proteomic Analysis From Offspring of Keratoconus Patients: New Insights Into Corneal Biomechanical Weakness and Disease Risk Stages. Invest Ophthalmol Vis Sci, 66(5):41(2025) [pubmed]

10.1167/iovs.66.5.41;

submitter keyword: Offspring, Keratoconus,Biomarkers, Proteomics, Tear fluid

Susana Belén Bravo López
contact affiliation	Instituto de Investigaciones Sanitarias de Santiago de Compostela
contact email	sbbravo@gmail.com
lab head
Susana Bravo
contact affiliation	FIDIS
contact email	sbbravo@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD049296

PRIDE project URI

• PRIDE
  1. PXD049296
     1. Label: PRIDE project
     2. Name: Proteomic Analysis of Tear Fluid from the Offspring of Keratoconus Patients Toward Novel Biomarkers and Pathways Associated with Corneal Biomechanical Weakness and Disease Susceptibility.