PXD049245
PXD049245 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | CKD-PROTEOME project, namely Calciprotein particle-activated endothelial cells exhibit altered mitochondria related to calcium dysregulation |
| Description | Chronic kidney disease (CKD) is associated with increased cardiovascular risk, morphologically characterized by vascular calcification (VC). In CKD, high serum phosphate levels result in enhanced calcification propensity and the formation of circulating crystalline nanoaggregates (calciprotein particles, CPP2) containing calcium, phosphate and serum proteins. CPP2 can induce VC directly and this is recapitulated in vascular smooth muscle cells (VSMCs) in vitro. Under physiological conditions, vascular endothelial cells (ECs), rather than VSMCs are primarily exposed to circulating CPP2. Knowledge on the modulating effects of ECs on VC development is still in its infancy. The aim of this study was to investigate the calcium and bioenergetics signaling in CPP2-induced EC, including using ECs global proteome. |
| HostingRepository | iProX |
| AnnounceDate | 2024-02-06 |
| AnnouncementXML | Submission_2024-02-07_07:23:37.237.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Benoit Bernay |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-02-07 07:22:30 | ID requested | |
| ⏵ 1 | 2024-02-07 07:23:37 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Chronic kidney disease, calciprotein particles, endothelial cell activation, mitochondria, calcium |
Contact List
| Laurent Chatre | |
|---|---|
| contact affiliation | Université de Caen Normandie, CNRS, Normandie Univ, ISTCT UMR6030, Caen, France |
| contact email | chatre@cyceron.fr |
| lab head | |
| Benoit Bernay | |
| contact affiliation | Université de Caen Normandie, US EMerode, Platform Proteogen, Caen, France |
| contact email | benoit.bernay@unicaen.fr |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
