PXD049225

PXD049225 is an original dataset announced via ProteomeXchange.

Title	Changes in the hippocampal proteome of chronic intermittent hypoxia mice
Description	Cognitive and behavioural scales have indicated chronic intermittent hypoxia (CIH)-induced abnormalities in learning, memory, and cognition . Although earlier studies have shown that CIH impacts adult hippocampal neurogenesis and cognitive processes, the exact mechanism through which CIH affects hippocampal function, particularly learning and memory, remains unclear. In this study, we employed Liquid chromatography-tandem mass spectrometry to examine the proteome of the hippocampus in mice exposed to CIH for or normoxia for 4 weeks. We identified 5729 proteins in the hippocampi of CIH and CON mice, 4878 of which were quantified via proteomic spectrogram analysis. Although numerous proteins were identified, only 21 proteins exhibited significant differences. In biological processes (BP) analysis, the majority of proteins were enriched in phagocytosis and immune response, especially in B cells. Furthermore, in the analysis of cellular components (CC), most of proteins showed enrichment in immunoglobulin complexes. Finally, in the analysis of molecular functions (MFs), a notable enrichment of these proteins in immunoglobulin receptor-binding activities was observed.
HostingRepository	iProX
AnnounceDate	2024-02-07
AnnouncementXML	Submission_2024-03-18_19:33:10.400.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fan Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-07 00:35:45	ID requested
1	2024-02-14 01:34:25	announced
⏵ 2	2024-03-18 19:33:11	announced	2024-03-19: Update information.

Liu F, Yan W, Chen C, Zeng Y, Kong Y, He X, Pei P, Wang S, Zhang T, Acetylome analyses provide novel insights into the effects of chronic intermittent hypoxia on hippocampus-dependent cognitive impairment. Front Mol Neurosci, 17():1324458(2024) [pubmed]

submitter keyword: Proteome, Hippocampus, chronic intermittent hypoxia, Bioinformatic

Shan Wang
contact affiliation	Children's Hospital Capital Institute of Pediatrics
contact email	598557219@qq.com
lab head
Fan Liu
contact affiliation	Children's Hospital Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
contact email	liufan5023@163.com
dataset submitter

iProX dataset URI