PXD049200

PXD049200 is an original dataset announced via ProteomeXchange.

Title	Proteomic characterization and comparison of the infective and adult life stage secretomes from Necator Americanus and Ancylostoma ceylanicum
Description	Parasitic infections with the hookworms Ancylostoma ceylanicum and Necator americanus are a significant global health burden and current hookworm infection management approaches are limited by modest drug efficacy, costs, risk of reinfection and drug resistance. Subunit vaccines based on proteins excreted and secreted (ES) by hookworms that impart sufficient efficacy to reduce worm numbers and associated disease burden is a promising management strategy to overcome these limitations. However, existing studies on the ES proteome of hookworms have mainly described proteins derived from the adult life stage which may preclude the opportunity to target larvae-specific parasitic processes. In this project, we use high resolution mass spectrometry to identify and compare ES proteins from the L3 stage as well as the adult stage of N. americanus and A. ceylanicum respectively.
HostingRepository	PRIDE
AnnounceDate	2024-12-19
AnnouncementXML	Submission_2024-12-19_02:12:35.690.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yide Wong
SpeciesList	scientific name: Ancylostoma ceylanicum; NCBI TaxID: 53326; scientific name: Necator americanus; NCBI TaxID: 51031;
ModificationList	acetylated residue; monohydroxylated residue
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-06 06:37:35	ID requested
⏵ 1	2024-12-19 02:12:36	announced

Dataset with its publication pending

submitter keyword: Ancylostoma ceylanicum, L3,Adult, Secretome, Necator americanus

Alex Loukas
contact affiliation	Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia
contact email	alex.loukas@jcu.edu.au
lab head
Yide Wong
contact affiliation	James Cook University
contact email	yide.wong@jcu.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD049200

PRIDE project URI

• PRIDE
  1. PXD049200
     1. Label: PRIDE project
     2. Name: Proteomic characterization and comparison of the infective and adult life stage secretomes from Necator Americanus and Ancylostoma ceylanicum