PXD049183

PXD049183 is an original dataset announced via ProteomeXchange.

Title	Proteomics of BACE2 inhibition on patient-derived EWS cells
Description	Ewing sarcoma (EWS), a highly aggressive cancer with limited treatment options and low survival rates. Transcriptomics revealed β-Secretase 2 (BACE2) presence while BACE2 inhibition attenuated EWS cell growth, abolished tumor-initiating capacity, and altered cell cycle/metastatic signatures. To further understand the mechanism of BACE2 inhibition in EWS, we performed a global proteomic analysis of BACE2-treated vs untreated EWS cells. The proteomic dataset revealed interference at various cellular levels following BACE2 inhibition, most of which was compatible with our findings in pPDX transcriptomics and in EWS cell-based assays, including modulation of the cell cycle, metastatic signature and PI3K/Akt-related pathways.
HostingRepository	PRIDE
AnnounceDate	2026-09-03
AnnouncementXML	Submission_2026-09-03_06:27:03.770.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Geiger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-05 07:55:56	ID requested
⏵ 1	2026-09-03 06:27:04	announced

Dataset with its publication pending

submitter keyword: proteomics, LC-MS, BACE2,Ewing Sarcoma, inhibition, cell line

Prof. Tamar Geiger
contact affiliation	Cancer proteomics lab Department of Molecular Cell Biology Weizmann Institute of science, Rehovot, Israel
contact email	tami.geiger@weizmann.ac.il
lab head
Tamar Geiger
contact affiliation	Weizmann Institute of Science
contact email	geiger@tauex.tau.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD049183

PRIDE project URI

• PRIDE
  1. PXD049183
     1. Label: PRIDE project
     2. Name: Proteomics of BACE2 inhibition on patient-derived EWS cells