PXD049146

PXD049146 is an original dataset announced via ProteomeXchange.

Title	Proteome, lysine acetylome and succinylome identify post-translational modification of STAT1 as a novel drug target in silicosis
Description	Inhalation of crystalline silica dust induces incurable lung damage, silicosis and pulmonary fibrosis. However, the mechanisms of the lung injury remain poorly understood, with limited therapeutic options aside from lung transplantation. Post-translational modifications can regulate the function of proteins and play an important role in studying disease mechanisms.To investigate changes in post-translational modifications of proteins in silicosis, combined quantitative proteome, acetylome, and succinylome analyses were performed with lung tissues from silica-injured and healthy mice using liquid chromatography-mass spectrometry. Combined analysis was applied to the three omics datasets to construct a protein landscape. The acetylation and succinylation of the key transcription factor STAT1 were found to play important roles in the silica-induced pathophysiological changes. Modulating the acetylation level of STAT1 with Teprenone effectively inhibited the progression of silicosis. This report revealed a comprehensive landscape of post-translational modifications in silica-injured mouse, presented a novel therapeutic strategy targeting the post-translational level for silica-induced lung diseases.
HostingRepository	iProX
AnnounceDate	2024-02-04
AnnouncementXML	Submission_2024-10-12_00:22:34.689.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juntao Yang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	acetylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-03 19:56:25	ID requested
1	2024-04-15 20:24:03	announced
⏵ 2	2024-10-12 00:22:35	announced	2024-10-12: Update information.

Zhang T, Wang Y, Sun Y, Song M, Pang J, Wang M, Zhang Z, Yang P, Chen Y, Qi X, Zhou H, Han Z, Xing Y, Liu Y, Li B, Liu J, Yang J, Wang J, Proteome, Lysine Acetylome, and Succinylome Identify Posttranslational Modification of STAT1 as a Novel Drug Target in Silicosis. Mol Cell Proteomics, 23(6):100770(2024) [pubmed]

submitter keyword: Proteome, lysine, acetylome, succinylome, silicosis

Juntao Yang
contact affiliation	Peking Union Medical College
contact email	superyjt79@163.com
lab head
Juntao Yang
contact affiliation	Peking Union Medical College
contact email	superyjt79@163.com
dataset submitter

iProX dataset URI