PXD049124

PXD049124 is an original dataset announced via ProteomeXchange.

Title	Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 2
Description	Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosome numbers. To identify molecular mechanisms of adaptation to aneuploidy, we initiated in vitro evolution of cells with extra chromosomes added via microcell-mediated chromosome transfer. To this end, we cultured cells in a nutrient-rich medium for 50 passages or plated the cells at a low density and selectively collected the largest colonies originating from a single cell (colony selection). The anaylsis of global proteomes of the evolved cell lines was then carried out using a TMT quantification strategy. This data set also includes data from trisomic cells with and without TP53 k.o.
HostingRepository	PRIDE
AnnounceDate	2025-01-14
AnnouncementXML	Submission_2025-01-14_09:51:32.375.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Markus Räschle
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-02 09:49:31	ID requested
⏵ 1	2025-01-14 09:51:32	announced

Dataset with its publication pending

submitter keyword: Cancer,Aneuploidy, Evolution, LC-MS/MS

Markus Räschle
contact affiliation	Molecular Genetics, RPTU Kaiserslautern
contact email	raeschle@rptu.de
lab head
Markus Räschle
contact affiliation	Technical University Kaiserslautern
contact email	raeschle@rhrk.uni-kl.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD049124

PRIDE project URI

• PRIDE
  1. PXD049124
     1. Label: PRIDE project
     2. Name: Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 2