PXD049107

PXD049107 is an original dataset announced via ProteomeXchange.

Title	[HPP-2.0] Phosphoproteome Profiling of uEV Reveals p-AQP2 and p-GSK3β as Potential Markers for Diabetic Nephropathy
Description	We used ultra-high-sensitivity quantitative phosphoproteomics to identify phosphoproteins in urinary extracellular vesicles (uEVs) as potential biomarkers of DN. We detected 233 phosphopeptides within the uEVs, with 47 phosphoproteins exhibiting significant alterations in patients with DN compared to those in patients with diabetes. From these phosphoproteins, we selected phosphorylated aquaporin-2 (p-AQP2[S256]) and phosphorylated glycogen synthase kinase-3β (p-GSK3β[Y216]) for validation, as they were significantly overrepresented in pathway analyses and previously implicated in DN pathogenesis.
HostingRepository	iProX
AnnounceDate	2024-02-01
AnnouncementXML	Submission_2024-02-01_23:10:37.595.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Feng Zhou
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-01 23:10:10	ID requested
⏵ 1	2024-02-01 23:10:37	announced

Dataset with its publication pending

submitter keyword: phosphoproteome, urinary extracellular vesicles, diabetic nephropathy, biomarker

Feng Zhou
contact affiliation	Institutes of Biomedical Sciences, Fudan University
contact email	zhou_feng@fudan.edu.cn
lab head
Feng Zhou
contact affiliation	Institutes of Biomedical Sciences, Fudan University
contact email	zhou_feng@fudan.edu.cn
dataset submitter

iProX dataset URI