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PXD049103

PXD049103 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe protein phosphorylation in HCT116 cells with or without the over-expressed LRRC8A
DescriptionIt’s hypothesized that LRRC8A may regulate cell proliferation and migration by participating in the transduction of cell signaling. Then protein phosphorylation in cells with or without the over-expressed LRRC8A was detected and quantified by mass spectroscopy. A total of 564 proteins and 1,102 phosphorylated sites were identified, of which 342 proteins and 538 phosphorylated sites were successfully quantified. A total of 32 downregulated and 68 upregulated proteins were noted in the OE-LRRC8A group compared with the LV-ctrl group; the intensities of 79 phosphorylated sites in 62 proteins were considerably altered by the overexpression of the LRRC8A protein; all the differential sites included 41 downregulated sites and 38 upregulated sites.
HostingRepositoryiProX
AnnounceDate2024-02-01
AnnouncementXMLSubmission_2024-03-31_20:11:17.906.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHaifeng Zhang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-02-01 21:22:19ID requested
12024-03-31 20:11:18announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: LRRC8A, protein phosphorylation, HCT116 cell
Contact List
Haifeng Zhang
contact affiliationXi'an Jiaotong University
contact emailzhf19841011@xjtu.edu.cn
lab head
Haifeng Zhang
contact affiliationXi'an Jiaotong University
contact emailzhf19841011@xjtu.edu.cn
dataset submitter
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