PXD049077 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification of the most immunoreactive antigens of Candida auris to sera from infected mice |
Description | Candida auris is a recently found pathogenic yeast that causes systemic infections, showing a high mortality rate. The delay on making a correct diagnosis of C. auris is a current problem in the healthcare system setting. As immunoproteomics studies are important to identify immunoreactive proteins for new diagnostic strategies, in this study immunocompetent murine systemic infections caused by non-aggregative and aggregative phenotypes of C. auris, and by Candida albicans and Candida haemulonii were carried out, and the obtained sera were used to study their immunoreactivity against C. auris proteins. The aim was to identify the most immunoreactive antigens of this yeast. Thirteen spots were recognized by sera from mice infected with both C. auris phenotypes and analyzed by mass spectrometry. They corresponded to enolase, phosphoglycerate kinase, glyceraldehyde 3-phosphate dehydrogenase and phosphoglycerate mutase. These four proteins seem to be also recognized by sera obtained from human patients with disseminated C. auris infection, but not by sera obtained from mice infected with other fungi such as C. albicans or Aspergillus fumigatus. In conclusion, this study showed that the identified proteins could be potential candidates to be studied as new diagnostic or even therapeutic targets for C. auris. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-23 |
AnnouncementXML | Submission_2024-06-23_01:17:15.531.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Aitziber Antoran |
SpeciesList | scientific name: [Candida] auris; NCBI TaxID: 498019; scientific name: Saccharomycetales; NCBI TaxID: NCBITaxon:4892; |
ModificationList | carbamoylated residue; monohydroxylated residue |
Instrument | Q Exactive HF; Orbitrap Exploris 240 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-02-01 02:58:43 | ID requested | |
⏵ 1 | 2024-06-23 01:17:16 | announced | |
Publication List
10.1021/acs.jproteome.3c00752; |
Areitio M, Antoran A, Rodriguez-Erenaga O, Aparicio-Fernandez L, Martin-Souto L, Buldain I, Zaldibar B, Ruiz-Gaitan A, Pem, รก, n J, Rementeria A, Ramirez-Garcia A, to IgGs from Systemic Infections in Mice. J Proteome Res, 23(5):1634-1648(2024) [pubmed] |
Keyword List
submitter keyword: Candida auris, antigen, systemic infections, proteome, western blot |
Contact List
Andoni Ramirez |
contact affiliation | Immunology, Microbiology and Parasitology Faculty of Science and Technology University of the Basque Country (UPV/EHU) Spain |
contact email | andoni.ramirez@ehu.eus |
lab head | |
Aitziber Antoran |
contact affiliation | University of the Basque Country (UPV/EHU) |
contact email | aitziber.antoran@ehu.eus |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD049077
- Label: PRIDE project
- Name: Identification of the most immunoreactive antigens of Candida auris to sera from infected mice