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PXD049069

PXD049069 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	FBXO7 Ubiquitinates PRMT1 to Suppress Serine Synthesis and Tumor Growth in HCC
Description	Cancer cells are often addicted to de novo serine synthesis to support their survival and rapid proliferation. However, how serine synthesis is regulated in cancer is not well understood. Our recent report demonstrated that protein arginine methyltransferase 1 (PRMT1) is upregulated in hepatocellular carcinoma (HCC) and methylates phosphoglycerate dehydrogenase (PHGDH, the first and rate-limiting enzyme in serine synthesis) at arginine 236, thereby activating PHGDH and promoting serine synthesis. Nevertheless, the mechanisms underlying upregulation of PRMT1 and regulation of PRMT1-PHGDH axis in HCC remain unknown. Here, using label-free quantitative proteomics analysis, we identified the potential interacting proteins of PRMT1.
HostingRepository	iProX
AnnounceDate	2024-02-01
AnnouncementXML	Submission_2024-01-31_22:38:44.437.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kui Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-31 22:38:20	ID requested
⏵ 1	2024-01-31 22:38:44	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: PRMT1 interacting protein

Contact List

Kui Wang
contact affiliation	Sichuan University
contact email	kuiwang@scu.edu.cn
lab head
Kui Wang
contact affiliation	Sichuan University
contact email	kuiwang@scu.edu.cn
dataset submitter

Full Dataset Link List

iProX dataset URI