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PXD049069

PXD049069 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFBXO7 Ubiquitinates PRMT1 to Suppress Serine Synthesis and Tumor Growth in HCC
DescriptionCancer cells are often addicted to de novo serine synthesis to support their survival and rapid proliferation. However, how serine synthesis is regulated in cancer is not well understood. Our recent report demonstrated that protein arginine methyltransferase 1 (PRMT1) is upregulated in hepatocellular carcinoma (HCC) and methylates phosphoglycerate dehydrogenase (PHGDH, the first and rate-limiting enzyme in serine synthesis) at arginine 236, thereby activating PHGDH and promoting serine synthesis. Nevertheless, the mechanisms underlying upregulation of PRMT1 and regulation of PRMT1-PHGDH axis in HCC remain unknown. Here, using label-free quantitative proteomics analysis, we identified the potential interacting proteins of PRMT1.
HostingRepositoryiProX
AnnounceDate2024-02-01
AnnouncementXMLSubmission_2024-01-31_22:38:44.437.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKui Wang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-31 22:38:20ID requested
⏵ 12024-01-31 22:38:44announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: PRMT1 interacting protein
Contact List
Kui Wang
contact affiliationSichuan University
contact emailkuiwang@scu.edu.cn
lab head
Kui Wang
contact affiliationSichuan University
contact emailkuiwang@scu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI

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