PXD049018

PXD049018 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	BJ cyto-nuclear translocation upon STING activation
Description	The goal of this project is to identify changes of cyto-nuclear import upon STING activation by cGAMP. BJ cells stably expressing TurboID-NES were treated with biotin to label cytoplasmic proteins, after which cells were further treated with or without cGAMP to activate STING signaling. Cells were then fractionated to collect the nuclei. The biotinylated proteins in the nuclear pellets were purified by streptavidin beads for mass spectrometry analysis.
HostingRepository	PRIDE
AnnounceDate	2024-09-19
AnnouncementXML	Submission_2024-09-19_08:44:07.228.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD049018
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jay Xiaojun Tan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-30 13:06:47	ID requested
⏵ 1	2024-09-19 08:44:07	announced

Publication List

10.6019/PXD049018;
10.1016/J.MOLCEL.2024.08.026;

10.6019/PXD049018;

10.1016/J.MOLCEL.2024.08.026;

Keyword List

submitter keyword: streptavidin purification,STING, biotinylation, cGAMP, nuclear import

submitter keyword: streptavidin purification,STING, biotinylation, cGAMP, nuclear import

Contact List

Jay Xiaojun Tan, PhD
contact affiliation	Assistant Professor Aging Institute Department of Cell Biology University of Pittsburgh School of Medicine/UPMC Bridgeside Point I Room 457 100 Technology Dr. Pittsburgh, PA 15219
contact email	Jay.Tan@pitt.edu
lab head
Jay Xiaojun Tan
contact affiliation	University of Pittsburgh
contact email	Jay.Tan@pitt.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD049018
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD049018

PRIDE project URI

Repository Record List

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