PXD049014

PXD049014 is an original dataset announced via ProteomeXchange.

Title	Quantitative secretome analysis of fetal and adult hematopoietic progenitors during leukemia initiation and its response to Fibulin and/or Fibronectin treatment.
Description	We describe the proteomic composition of the secretome of fetal and adult hematopoietic progenitors during MLL-rearranged (MLLr) leukemia initiation as well as the pre-leukemic cells’ secretion response to the treatment with Fibulin (Fbln1) and/or Fibronectin (Fn1) using data-independent acquisition mass spectrometry analysis.
HostingRepository	PRIDE
AnnounceDate	2024-04-02
AnnouncementXML	Submission_2024-04-02_07:06:07.416.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sudip Ghosh
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-30 09:59:47	ID requested
⏵ 1	2024-04-02 07:06:08	announced

Jassinskaja M, Ghosh S, Watral J, Davoudi M, Claesson Stern M, Daher U, Eldeeb M, Zhang Q, Bryder D, Hansson J, A complex interplay of intra- and extracellular factors regulates the outcome of fetal- and adult-derived MLL-rearranged leukemia. Leukemia, ():(2024) [pubmed]

10.1038/s41375-024-02235-5;

submitter keyword: bone marrow, Leukemia,Secretome, Extracellular, Fetal liver, data-independent acquisition, Hematopoietic Progenitors

Dr. Jenny Hansson
contact affiliation	Proteomic Hematology Department of Experimental Medical Science Lund Stem Cell Center, Lund University BMC B12, 22184 Lund, Sweden
contact email	jenny.hansson@med.lu.se
lab head
Sudip Ghosh
contact affiliation	Proteomic Hematology, Department of Experimental Medical Science, Lund Stem Cell Center, Lund University
contact email	sudip.ghosh@med.lu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD049014

PRIDE project URI

• PRIDE
  1. PXD049014
     1. Label: PRIDE project
     2. Name: Quantitative secretome analysis of fetal and adult hematopoietic progenitors during leukemia initiation and its response to Fibulin and/or Fibronectin treatment.