PXD048991

PXD048991 is an original dataset announced via ProteomeXchange.

Title	Unveiling the development specific regenerative potential of spinal cord: insights from extracellular matrix
Description	Neonatal spinal cord tissues exhibit remarkable regenerative capabilities than adult tissues after injury, but the role of extracellular matrix (ECM) in this process has remained elusive. Here we found that early developmental spinal cord had higher levels of ECM proteins associated with neural development and axon growth, but fewer inhibitory proteoglycans compared to adult spinal cord. Decellularized spinal cord ECM from neonatal (DNSCM) and adult (DASCM) rabbits preserved these differences. DNSCM promoted proliferation, migration, and neuronal differentiation of neural progenitor cells (NPCs), and facilitated axonal outgrowth and regeneration of spinal cord organoids than DASCM. Pleiotrophin (PTN) and Tenascin (TNC) in DNSCM were identified as contributors to these abilities. Furthermore, DNSCM demonstrated superior performance as a delivery vehicle for NPCs and organoids in rats with spinal cord injury (SCI). It suggests that ECM cues from early development stages might significantly contribute to the prominent regeneration ability in spinal cord.
HostingRepository	iProX
AnnounceDate	2024-01-29
AnnouncementXML	Submission_2024-02-27_23:05:44.370.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sun Zheng
SpeciesList	scientific name: Oryctolagus cuniculus; NCBI TaxID: 9986;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-29 19:15:47	ID requested
⏵ 1	2024-02-27 23:05:44	announced

Dataset with its publication pending

submitter keyword: spinal cord injury, axon regeneration, extracellular matrix, spinal cord organoid, neural progenitor cells.

Yannan Zhao
contact affiliation	State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
contact email	ynzhao@genetics.ac.cn
lab head
Sun Zheng
contact affiliation	Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
contact email	sunzheng@genetics.ac.cn
dataset submitter

iProX dataset URI