PXD048988

PXD048988 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteome and Phosphoproteome of colorectal cancer liver metastases (CRLM), phosphoproteomics of AZD6482 treated CRC cell lines, phosphoproteomics of copanlisib treated xenograft
Description	The research focuses on the longitudinal analysis of phosphoproteomic profiles in patients with recurrent colorectal liver metastases. Twenty-four individuals who underwent initial and recurrent resections for colorectal liver metastases participated in the study. Tissue samples were systematically collected throughout the treatment period from the liver metastases and normal liver tissue of each of the 24 patients at two timepoints. To validate the therapeutic candidate, we conducted a phosphoproteomics analysis of cell lines treated with AZD6482 and xenograft samples treated with copanlisib. The analysis aimed to assess the pharmacological effects of these treatments.
HostingRepository	jPOST
AnnounceDate	2025-01-30
AnnouncementXML	Submission_2025-01-29_07:00:07.796.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daigo Gunji
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine
Instrument	Q Exactive; Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-29 17:36:02	ID requested
⏵ 1	2025-01-29 07:00:08	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: human, tissue, cell line, xenograft, TMT, IMAC, pY enrichement

submitter keyword: human, tissue, cell line, xenograft, TMT, IMAC, pY enrichement

Contact List

Jun Adachi
lab head
Daigo Gunji
contact affiliation	National Institute of Biomedical Innovation
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002422/