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PXD048988

PXD048988 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome and Phosphoproteome of colorectal cancer liver metastases (CRLM), phosphoproteomics of AZD6482 treated CRC cell lines, phosphoproteomics of copanlisib treated xenograft
DescriptionThe research focuses on the longitudinal analysis of phosphoproteomic profiles in patients with recurrent colorectal liver metastases. Twenty-four individuals who underwent initial and recurrent resections for colorectal liver metastases participated in the study. Tissue samples were systematically collected throughout the treatment period from the liver metastases and normal liver tissue of each of the 24 patients at two timepoints. To validate the therapeutic candidate, we conducted a phosphoproteomics analysis of cell lines treated with AZD6482 and xenograft samples treated with copanlisib. The analysis aimed to assess the pharmacological effects of these treatments.
HostingRepositoryjPOST
AnnounceDate2025-01-30
AnnouncementXMLSubmission_2025-01-29_07:00:07.796.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDaigo Gunji
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListS-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine
InstrumentQ Exactive; Orbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-29 17:36:02ID requested
12025-01-29 07:00:08announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: human, tissue, cell line, xenograft, TMT, IMAC, pY enrichement
Contact List
Jun Adachi
lab head
Daigo Gunji
contact affiliationNational Institute of Biomedical Innovation
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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