PXD048972

PXD048972 is an original dataset announced via ProteomeXchange.

Title	Ancient tooth enamel proteomes to help understand post mortem protein degradation over millions of years
Description	The tooth enamel proteome is enzymatically broken down during development, which leads to a heterogenous distribution of remaining peptides of a protein sequence in a grown individual's enamelome. After death of the organism, the heterogeneous distribution of remaining peptides may be enhanced, as the proteome further degrades. The pattern of this degradation is poorly understood, but it might happen at different rates depending on the site within the protein sequence, due to different chemical properties of the peptides and their interaction with the environment. To learn more about this process, we recovered six ancient enamel proteomes from Equidae and Proboscidea fossils from Spain. The fossils span an age range of <100 ka to 11.6 Ma.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_12:55:38.388.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Johanna Krueger
SpeciesList	scientific name: Equidae; NCBI TaxID: 9788; scientific name: Proboscidea ; NCBI TaxID: 9779;
ModificationList	2-pyrrolidone-5-carboxylic acid (Glu); 2-pyrrolidone-5-carboxylic acid (Gln); phosphorylated residue; monohydroxylated residue; monohydroxylated proline; deamidated residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-29 06:46:05	ID requested
⏵ 1	2025-05-06 12:55:39	announced

Fong-Zazueta R, Krueger J, Alba DM, Aymerich X, Beck RMD, Cappellini E, Carrillo-Martin G, Cirilli O, Clark N, Cornejo OE, Farh KK, Ferr, á, ndez-Peral L, Juan D, Kelley JL, Kuderna LFK, Little J, Orkin JD, Paterson RS, Pawar H, Marques-Bonet T, Lizano E, Phylogenetic Signal in Primate Tooth Enamel Proteins and its Relevance for Paleoproteomics. Genome Biol Evol, 17(2):(2025) [pubmed]

10.1093/gbe/evaf007;

submitter keyword: Proboscidea, Paleoproteomics,Equidae, Ancient, Enamel

Tomas Marques-Bonet
contact affiliation	PRBB, Institute of Evolutionary Biology (UPF-CSIC), Dr. Aiguader 88, 8003 Barcelona, Spain Catalan Institution of Research and Advanced Studies (ICREA), Passeig de Lluís Companys, 23, 08010, Barcelona, Spain Centro Nacional de Análisis Genómico (CNAG), Baldiri i Reixac 4, 08028 Barcelona, Spain Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona Edifici ICTA-ICP, c/ Columnes s/n, 08193 Cerdanyola del Vallès, Barcelona, Spain
contact email	tomas.marques@upf.edu
lab head
Johanna Krueger
contact affiliation	Universitat Pompeu Fabra
contact email	uni.johanna.krueger@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD048972

PRIDE project URI

• PRIDE
  1. PXD048972
     1. Label: PRIDE project
     2. Name: Ancient tooth enamel proteomes to help understand post mortem protein degradation over millions of years