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PXD048972

PXD048972 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAncient tooth enamel proteomes to help understand post mortem protein degradation over millions of years
DescriptionThe tooth enamel proteome is enzymatically broken down during development, which leads to a heterogenous distribution of remaining peptides of a protein sequence in a grown individual's enamelome. After death of the organism, the heterogeneous distribution of remaining peptides may be enhanced, as the proteome further degrades. The pattern of this degradation is poorly understood, but it might happen at different rates depending on the site within the protein sequence, due to different chemical properties of the peptides and their interaction with the environment. To learn more about this process, we recovered six ancient enamel proteomes from Equidae and Proboscidea fossils from Spain. The fossils span an age range of <100 ka to 11.6 Ma.
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_12:55:38.388.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJohanna Krueger
SpeciesList scientific name: Equidae; NCBI TaxID: 9788; scientific name: Proboscidea ; NCBI TaxID: 9779;
ModificationList2-pyrrolidone-5-carboxylic acid (Glu); 2-pyrrolidone-5-carboxylic acid (Gln); phosphorylated residue; monohydroxylated residue; monohydroxylated proline; deamidated residue
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-29 06:46:05ID requested
12025-05-06 12:55:39announced
Publication List
Fong-Zazueta R, Krueger J, Alba DM, Aymerich X, Beck RMD, Cappellini E, Carrillo-Martin G, Cirilli O, Clark N, Cornejo OE, Farh KK, Ferr, á, ndez-Peral L, Juan D, Kelley JL, Kuderna LFK, Little J, Orkin JD, Paterson RS, Pawar H, Marques-Bonet T, Lizano E, Phylogenetic Signal in Primate Tooth Enamel Proteins and its Relevance for Paleoproteomics. Genome Biol Evol, 17(2):(2025) [pubmed]
10.1093/gbe/evaf007;
Keyword List
submitter keyword: Proboscidea, Paleoproteomics,Equidae, Ancient, Enamel
Contact List
Tomas Marques-Bonet
contact affiliationPRBB, Institute of Evolutionary Biology (UPF-CSIC), Dr. Aiguader 88, 8003 Barcelona, Spain Catalan Institution of Research and Advanced Studies (ICREA), Passeig de Lluís Companys, 23, 08010, Barcelona, Spain Centro Nacional de Análisis Genómico (CNAG), Baldiri i Reixac 4, 08028 Barcelona, Spain Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona Edifici ICTA-ICP, c/ Columnes s/n, 08193 Cerdanyola del Vallès, Barcelona, Spain
contact emailtomas.marques@upf.edu
lab head
Johanna Krueger
contact affiliationUniversitat Pompeu Fabra
contact emailuni.johanna.krueger@gmail.com
dataset submitter
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Dataset FTP location
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