PXD048967

PXD048967 is an original dataset announced via ProteomeXchange.

Title	Molecular signatures of Haemonchus contortus infection in sheep: a serum proteomics study on susceptible and tolerant sheep breeds
Description	Haemonchus contortus is the gastrointestinal nematode (GIN) species that most parasites sheep and goats in tropical and subtropical regions. Due to the high prevalence and pathogenicity by hematophagy, it causes severe anemia, submandibular edema and deaths. Post-genomics tools, such as proteomics, allow the identification of differentially expressed genes and differentially abundant proteins and metabolites between two conditions of a given factor. Thus, the detection of protein profiles that occur in more parasitized animals may be of great interest for the identification of sheep that effectively need anthelmintic treatment. As a result, the parasites are preserved in refugia through Targeted Selective Treatment (TST) strategies for the animals, extension of the period of efficacy of the anthelmintics and, when its use is necessary, parasite control will be more efficient. This project aims to characterize the plasma proteomic profile of sheep breeds susceptible and resistant to GIN infection, aiming at the future development of a diagnostic tool and the understanding of the resistance mechanisms involved in the Santa Inês, White Dorper and Texel sheep breeds. In this way, the development of methodologies, processes and products for the identification of sheep with higher rates of infection by GIN, in addition to the detection of breeds/individuals more resistant to these parasites and the understanding of the resistance mechanisms involved in the different hosts, is presented as a topic of great relevance for sheep farming, which can be extended to goat farming. It also addresses public health issues and the consumer population, which is increasingly demanding in terms of quality, certification and safety.
HostingRepository	PRIDE
AnnounceDate	2024-11-26
AnnouncementXML	Submission_2024-11-26_08:02:34.912.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ana Carolina Chagas
SpeciesList	scientific name: Ovis aries; NCBI TaxID: 9940;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-29 03:57:59	ID requested
1	2024-11-25 09:31:25	announced
⏵ 2	2024-11-26 08:02:35	announced	2024-11-26: Updated project metadata.

Chagas ACS, Ribeiro DM, Os, ó, rio H, Abreu AAP, Okino CH, Niciura SCM, Amarante AFT, Bello HJS, Melito GR, Esteves SN, Almeida AM, Molecular signatures of Haemonchus contortus infection in sheep: A comparative serum proteomic study on susceptible and resistant sheep breeds. Vet Parasitol, 331():110280(2024) [pubmed]

10.1016/j.vetpar.2024.110280;

submitter keyword: host resistance,Haemonchus contortus, proteomics, Dorper, Santa Inês, sheep

Ana Carolina de Souza Chagas
contact affiliation	Embrapa Pecuária Sudeste/Embrapa Southeastern Livestock Unit Brazilian Agricultural Research Corporation (Embrapa) São Carlos, São Paulo, Brazil
contact email	carolina.chagas@embrapa.br
lab head
Ana Carolina Chagas
contact affiliation	Brazilian Agricultural Research Corporation (Embrapa) Embrapa Southeastern Livestock Unit
contact email	carolina.chagas@embrapa.br
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/11/PXD048967

PRIDE project URI

• PRIDE
  1. PXD048967
     1. Label: PRIDE project
     2. Name: Molecular signatures of Haemonchus contortus infection in sheep: a serum proteomics study on susceptible and tolerant sheep breeds