PXD048965 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Using the HA tagged PAICS immunoprecipitation combined with LC-MS for identification of the acetylation sites of PAICS protein in senescent human IMR90 cells at day 10 post oncogene RAS activation |
Description | Senescence-associated secretory phenotype (SASP), an established feature of cellular senescence, mediates the biological impacts of senescent cells on tissue microenvironments and contributes to ageing-associated disease progression. We used proximity labeling by turboID combined with LC-MS and identified PAICS, a key enzyme for purine metabolism which interacts with ACSS2. PAICS can be acetylated and the acetylation promotes autophagy-mediated degradation to limit purine metabolism and reduces dNTP pools for DNA damage repair, which results in cytoplasmic chromatin fragment (CCF) accumulation and SASP. |
HostingRepository | PRIDE |
AnnounceDate | 2025-02-13 |
AnnouncementXML | Submission_2025-02-12_17:48:32.272.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yang Li |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-01-29 02:59:56 | ID requested | |
⏵ 1 | 2025-02-12 17:48:32 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, IMR90, LC-MS |
Contact List
Pingyu Liu |
contact affiliation | Human Phenome Institute,Zhangjiang FudanInternational Innovation Center, Fudan UniversityShanghai, 201203, China. |
contact email | pingyu_liu@fudan.edu.cn |
lab head | |
Yang Li |
contact affiliation | fudan university |
contact email | yangleduo1998@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048965
- Label: PRIDE project
- Name: Using the HA tagged PAICS immunoprecipitation combined with LC-MS for identification of the acetylation sites of PAICS protein in senescent human IMR90 cells at day 10 post oncogene RAS activation