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PXD048965

PXD048965 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleUsing the HA tagged PAICS immunoprecipitation combined with LC-MS for identification of the acetylation sites of PAICS protein in senescent human IMR90 cells at day 10 post oncogene RAS activation
DescriptionSenescence-associated secretory phenotype (SASP), an established feature of cellular senescence, mediates the biological impacts of senescent cells on tissue microenvironments and contributes to ageing-associated disease progression. We used proximity labeling by turboID combined with LC-MS and identified PAICS, a key enzyme for purine metabolism which interacts with ACSS2. PAICS can be acetylated and the acetylation promotes autophagy-mediated degradation to limit purine metabolism and reduces dNTP pools for DNA damage repair, which results in cytoplasmic chromatin fragment (CCF) accumulation and SASP.
HostingRepositoryPRIDE
AnnounceDate2025-02-13
AnnouncementXMLSubmission_2025-02-12_17:48:32.272.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYang Li
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-29 02:59:56ID requested
12025-02-12 17:48:32announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, IMR90, LC-MS
Contact List
Pingyu Liu
contact affiliationHuman Phenome Institute,Zhangjiang FudanInternational Innovation Center, Fudan UniversityShanghai, 201203, China.
contact emailpingyu_liu@fudan.edu.cn
lab head
Yang Li
contact affiliationfudan university
contact emailyangleduo1998@163.com
dataset submitter
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Dataset FTP location
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Repository Record List
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