PXD048883 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Sex-Dependent effects of Sortilin antisense oligonucleotide on Ldlr-/- mice |
| Description | We evaluated the therapeutic potential of silencing sortilin expression in vivo using antisense oligonucleotide (ASO-Sort1) to reduce atherosclerosis and associated calcification. Male and female Ldl (low-density lipoprotein) receptor deficient mice were fed a high-fat diet and treated with ASO-Sort1 for 15 weeks. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-15 |
| AnnouncementXML | Submission_2026-06-14_18:27:30.634.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD048883 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Adrien Lupieri |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-01-25 07:13:31 | ID requested | |
| ⏵ 1 | 2026-06-14 18:27:31 | announced | |
Publication List
| 10.6019/PXD048883; |
| 10.1161/atvbaha.124.321999; |
| Lupieri A, Becker-Greene D, Le TD, Roschel MM, Jha PK, Sonawane AR, Mullick A, Tsimikas S, Kuraoka S, Singh SA, Aikawa M, Aikawa E, Antisense Oligonucleotide Targeting Sortilin Reduces Vascular Calcification in Mice in a Sex-Dependent Manner. Arterioscler Thromb Vasc Biol, 45(8):1398-1415(2025) [pubmed] |
Keyword List
| submitter keyword: sortilin,Mouse, sex, Ldlr, aortic arch, atherosclerosis |
Contact List
| Dr Elena |
|---|
| contact affiliation | The Center for Excellence in Vascular Biology, Cardiovascular Division The Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA |
| contact email | eaikawa@bwh.harvard.edu |
| lab head | |
| Adrien Lupieri |
|---|
| contact affiliation | Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA |
| contact email | adrien.lupieri@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD048883 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048883
- Label: PRIDE project
- Name: Sex-Dependent effects of Sortilin antisense oligonucleotide on Ldlr-/- mice
