PXD048854
PXD048854 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for the treatment of acute myeloid leukemia |
| Description | Acute myeloid leukemia (AML) is a fatal disease characterized by a bleak prognosis. For over four decades, treatment options for AML have been constrained to administering high-dose cytotoxic chemotherapy. However, the emergence of drug resistance and the resultant toxic side effects have created an urgent necessity for identifying novel therapeutic targets. In this study, non-receptor protein tyrosine phosphatase type 2 (PTPN2) is highly expressed in AML. Remarkably, knock down of PTPN2 expression markedly mitigated AML burden both in vitro and in vivo. Additionally, we unveiled the direct interaction between PTPN2 and C-MYC, establishing C-MYC as a direct acting substrate of PTPN2. Then, we performed a small-molecule compound screening to identify K73, a selective inhibitor of PTPN2. At the same time, K73 showed a good safety profile and exhibited strong activity against AML in vivo. In conclusion, we have pinpointed a considerable therapeutic potential in targeting PTPN2 for AML treatment and discovered a novel class of selective PTPN2 inhibitors suitable for AML therapy. |
| HostingRepository | iProX |
| AnnounceDate | 2024-01-24 |
| AnnouncementXML | Submission_2024-01-24_18:38:40.083.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Wenbin Kuang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-01-24 18:36:22 | ID requested | |
| ⏵ 1 | 2024-01-24 18:38:40 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: PTPN2, C-MYC, acute myeloid leukemia, cell cycle, small molecule inhibitor |
Contact List
| Peng Yang | |
|---|---|
| contact affiliation | China Pharmaceutical University |
| contact email | pengyang@cpu.edu.cn |
| lab head | |
| Wenbin Kuang | |
| contact affiliation | China Pharmaceutical University |
| contact email | 1520220107@cpu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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