PXD048837

PXD048837 is an original dataset announced via ProteomeXchange.

Title	Proteome of cerebral thrombi retrieved in acute phase of stroke (ThrombiOMIC)
Description	The proteome of cerebral thrombi from patients recanalized by mechanical thrombectomy in an acute phase of stroke was carried out to determine biomarkers of stroke radio-clinical outcomes for stroke physicians (clinical outcome and mortality at 3 months, intracranial hemorrhagic transformation, etc.). Proteome of cerebral thrombi was also used to elucidate stroke physiopathology (paradoxical effect of glucose in acute phase of stroke) and evaluate recanalization treatments (intravenous thrombolysis by rt-PA and/or thrombectomy efficiency). ThrombiOMIC database was incremented by proteomic analyses of cerebral thrombi successfully retrieved from all consecutive stroke patients (n=59) with large vessel occlusion treated by mechanical thrombectomy in acute phase between October 2018 and August 2019 in the intensive care stroke unit of the University Hospital of Nice (France).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:28:02.204.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD048837
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Laurent SUISSA
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-24 07:20:02	ID requested
1	2024-01-28 08:06:44	announced
⏵ 2	2024-10-22 06:28:06	announced	2024-10-22: Updated project metadata.

10.1161/strokeaha.120.032129;

10.6019/PXD048837;

10.3390/metabo10120483;

Suissa L, Guigonis JM, Graslin F, Robinet-Borgomano E, Chau Y, Sedat J, Lindenthal S, Pourcher T, Combined Omic Analyzes of Cerebral Thrombi: A New Molecular Approach to Identify Cardioembolic Stroke Origin. Stroke, 52(9):2892-2901(2021) [pubmed]

Suissa L, Guigonis JM, Graslin F, Doche E, Osman O, Chau Y, Sedat J, Lindenthal S, Pourcher T, Metabolome of Cerebral Thrombi Reveals an Association between High Glycemia at Stroke Onset and Good Clinical Outcome. Metabolites, 10(12):(2020) [pubmed]

ProteomeXchange project tag: Cardiovascular (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: Human, LC-MSMS, Thrombus, Stroke, Proteomics

SUISSA Laurent
contact affiliation	TIRO-MATOs, Faculté de Médecine, 28 Ave de Valombrose, 06107 Nice, France C2VN, Faculté de Médecine, Bd Jean Moulin, 13005 Marseille, France
contact email	laurent.suissa@ap-hm.fr
lab head
Laurent SUISSA
contact affiliation	Stroke Unit - University Hospital of Marseille (France) C2VN - Aix-Marseille University (France)
contact email	laurent.suissa@ap-hm.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD048837

PRIDE project URI

• PRIDE
  1. PXD048837
     1. Label: PRIDE project
     2. Name: Proteome of cerebral thrombi retrieved in acute phase of stroke (ThrombiOMIC)