PXD048730 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Integrated proteomics reveals autophagy degradation landscape in neurons and receptors regulating neuronal activity |
Description | Autophagy is a constitutive process of lysosomal degradation required for maintaining the homeostasis of large molecular complexes and organelles in neurons. Here we reported a systemic investigation of neuronal autophagy targets through integrated proteomics and functional analysis. Proteomic profiling of human and mouse neurons with autophagy inhibition and LC3-interactome reveals a role for neuronal autophagy in targeting a wide range of cellular pathways and organelles. Our study reveals the landscape of autophagy degradation in neurons and insight into mechanisms of neurological disorders linked to autophagy deficiency. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-22 |
AnnouncementXML | Submission_2024-06-22_09:33:02.893.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Haiyan Tan |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue |
Instrument | Q Exactive HF; Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-01-20 14:28:52 | ID requested | |
⏵ 1 | 2024-06-22 09:33:03 | announced | |
Publication List
10.1038/s41467-024-47440-z; |
Zhou X, Lee YK, Li X, Kim H, Sanchez-Priego C, Han X, Tan H, Zhou S, Fu Y, Purtell K, Wang Q, Holstein GR, Tang B, Peng J, Yang N, Yue Z, Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons. Nat Commun, 15(1):3113(2024) [pubmed] |
Keyword List
submitter keyword: mass spectrometry,neuron, autophagy degradation, integrated Proteomics, tandem mass tag, LC-MS/MS |
Contact List
Junmin Peng |
contact affiliation | Department of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
contact email | Junmin.peng@stjude.org |
lab head | |
Haiyan Tan |
contact affiliation | St Jude Children's Research Hospital |
contact email | haiyan.tan@stjude.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD048730 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048730
- Label: PRIDE project
- Name: Integrated proteomics reveals autophagy degradation landscape in neurons and receptors regulating neuronal activity