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PXD048730

PXD048730 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIntegrated proteomics reveals autophagy degradation landscape in neurons and receptors regulating neuronal activity
DescriptionAutophagy is a constitutive process of lysosomal degradation required for maintaining the homeostasis of large molecular complexes and organelles in neurons. Here we reported a systemic investigation of neuronal autophagy targets through integrated proteomics and functional analysis. Proteomic profiling of human and mouse neurons with autophagy inhibition and LC3-interactome reveals a role for neuronal autophagy in targeting a wide range of cellular pathways and organelles. Our study reveals the landscape of autophagy degradation in neurons and insight into mechanisms of neurological disorders linked to autophagy deficiency.
HostingRepositoryPRIDE
AnnounceDate2024-06-22
AnnouncementXMLSubmission_2024-06-22_09:33:02.893.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHaiyan Tan
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; monohydroxylated residue
InstrumentQ Exactive HF; Orbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-20 14:28:52ID requested
12024-06-22 09:33:03announced
Publication List
10.1038/s41467-024-47440-z;
Zhou X, Lee YK, Li X, Kim H, Sanchez-Priego C, Han X, Tan H, Zhou S, Fu Y, Purtell K, Wang Q, Holstein GR, Tang B, Peng J, Yang N, Yue Z, Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons. Nat Commun, 15(1):3113(2024) [pubmed]
Keyword List
submitter keyword: mass spectrometry,neuron, autophagy degradation, integrated Proteomics, tandem mass tag, LC-MS/MS
Contact List
Junmin Peng
contact affiliationDepartment of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
contact emailJunmin.peng@stjude.org
lab head
Haiyan Tan
contact affiliationSt Jude Children's Research Hospital
contact emailhaiyan.tan@stjude.org
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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