PXD048730

PXD048730 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Integrated proteomics reveals autophagy degradation landscape in neurons and receptors regulating neuronal activity
Description	Autophagy is a constitutive process of lysosomal degradation required for maintaining the homeostasis of large molecular complexes and organelles in neurons. Here we reported a systemic investigation of neuronal autophagy targets through integrated proteomics and functional analysis. Proteomic profiling of human and mouse neurons with autophagy inhibition and LC3-interactome reveals a role for neuronal autophagy in targeting a wide range of cellular pathways and organelles. Our study reveals the landscape of autophagy degradation in neurons and insight into mechanisms of neurological disorders linked to autophagy deficiency.
HostingRepository	PRIDE
AnnounceDate	2024-06-22
AnnouncementXML	Submission_2024-06-22_09:33:02.893.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haiyan Tan
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue
Instrument	Q Exactive HF; Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-20 14:28:52	ID requested
⏵ 1	2024-06-22 09:33:03	announced

Publication List

10.1038/s41467-024-47440-z;
Zhou X, Lee YK, Li X, Kim H, Sanchez-Priego C, Han X, Tan H, Zhou S, Fu Y, Purtell K, Wang Q, Holstein GR, Tang B, Peng J, Yang N, Yue Z, Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons. Nat Commun, 15(1):3113(2024) [pubmed]

10.1038/s41467-024-47440-z;

Zhou X, Lee YK, Li X, Kim H, Sanchez-Priego C, Han X, Tan H, Zhou S, Fu Y, Purtell K, Wang Q, Holstein GR, Tang B, Peng J, Yang N, Yue Z, Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons. Nat Commun, 15(1):3113(2024) [pubmed]

Keyword List

submitter keyword: mass spectrometry,neuron, autophagy degradation, integrated Proteomics, tandem mass tag, LC-MS/MS

submitter keyword: mass spectrometry,neuron, autophagy degradation, integrated Proteomics, tandem mass tag, LC-MS/MS

Contact List

Junmin Peng
contact affiliation	Department of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
contact email	Junmin.peng@stjude.org
lab head
Haiyan Tan
contact affiliation	St Jude Children's Research Hospital
contact email	haiyan.tan@stjude.org
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD048730

PRIDE project URI

Repository Record List

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