PXD048717

PXD048717 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	the Urine proteomics of pulmonary tuberculosis
Description	In the present study, we aimed to identify biomarkers for diagnosis of pulmonary tuberculosis (PTB) using urinary metabolomic and proteomic analysis. Methods: 40 urine samples were collected from PTB, lung cancer (LCA), community-acquired pneumonia (CAP) patients and healthy controls (HC), respectively. Biomarker panels were selected based on random forest (RF) analysis. Results: A total of 3,868 proteins and 47,528 metabolic features detected using pairwise comparisons. Using AUC≥0.8000 as a cutoff value, we picked up five protein biomarkers for PTB diagnosis. The five-protein panel yielded an AUC of PTB/HC, PTB/CAP and PTB/LCA were 0.9840, 0.9680 and 0.9310, respectively. Additionally, five metabolism biomarkers were selected for differential diagnosis purpose. By employment of the five-metabolism panel, we could differentiate PTB/HC at an AUC of 0.9940, PTB/CAP of 0.8920, and PTB/LCA of 0.8570, respectively. When the five protein and five metabolism biomarkers were combined, yielded an AUC of PTB/HC, PTB/CAP and PTB/LCA were 1.0000, 0.9220 and 0.9500, respectively. Conclusion: Our data demonstrate that the combination of metabolomic and proteomic analyses can identify a novel urine biomarker panel to diagnose PTB with high sensitivity and specificity.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_12:54:07.833.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	kaixin zhong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-19 10:17:21	ID requested
⏵ 1	2025-05-06 12:54:08	announced

Publication List

10.1186/s12014-024-09514-4;
Yu J, Yuan J, Liu Z, Ye H, Lin M, Ma L, Liu R, Ding W, Li L, Ma T, Tang S, Pang Y, Combined urine proteomics and metabolomics analysis for the diagnosis of pulmonary tuberculosis. Clin Proteomics, 21(1):66(2024) [pubmed]

10.1186/s12014-024-09514-4;

Yu J, Yuan J, Liu Z, Ye H, Lin M, Ma L, Liu R, Ding W, Li L, Ma T, Tang S, Pang Y, Combined urine proteomics and metabolomics analysis for the diagnosis of pulmonary tuberculosis. Clin Proteomics, 21(1):66(2024) [pubmed]

Keyword List

submitter keyword: Proteomics
Metabolomics
Tuberculosis
Biomarkers
Urine

submitter keyword: Proteomics

Metabolomics

Tuberculosis

Biomarkers

Urine

Contact List

Yu Pang
contact affiliation	Beijing Chest Hospital
contact email	pangyupound@163.com
lab head
kaixin zhong
contact affiliation	shanghai bioprofile technology company
contact email	zhongkaixin@bioprofile.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD048717
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD048717

PRIDE project URI

Repository Record List

[ + ]