PXD048666
PXD048666 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex |
Description | We utilized a large-scale proteomic profiling strategy to quantitatively measure ADP-riboxanation (and classical ADP-ribosylation) levels of host proteins upon introduction of bacterial effectors. Notably, we identified the eukaryotic translation initiation factor 3 (eIF3) complex as a novel target of the OspC family proteins. ADP-riboxanation of eIF3 resulted in inhibition of bulk protein synthesis and SG assembly in infected host cells, which promoted intracellular bacterial proliferation. |
HostingRepository | iProX |
AnnounceDate | 2024-01-18 |
AnnouncementXML | Submission_2024-05-09_20:53:46.769.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Wei Xian |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-01-17 23:07:45 | ID requested | |
1 | 2024-01-17 23:08:05 | announced | |
⏵ 2 | 2024-05-09 20:53:47 | announced | 2024-05-10: Update information. |
Publication List
Zhang Q, Xian W, Li Z, Lu Q, Chen X, Ge J, Tang Z, Liu B, Chen Z, Gao X, Hottiger MO, Zhang P, Qiu J, Shao F, Liu X, Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex. Cell Rep, 43(2):113789(2024) [pubmed] |
Keyword List
submitter keyword: ADP-riboxanation, stress granule |
Contact List
Xiaoyun Liu | |
---|---|
contact affiliation | Peking University Health Science Center |
contact email | xiaoyun.liu@bjmu.edu.cn |
lab head | |
Wei Xian | |
contact affiliation | Peking University Health Science Center |
contact email | xianwei@pku.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |