PXD048666

PXD048666 is an original dataset announced via ProteomeXchange.

Title	Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex
Description	We utilized a large-scale proteomic profiling strategy to quantitatively measure ADP-riboxanation (and classical ADP-ribosylation) levels of host proteins upon introduction of bacterial effectors. Notably, we identified the eukaryotic translation initiation factor 3 (eIF3) complex as a novel target of the OspC family proteins. ADP-riboxanation of eIF3 resulted in inhibition of bulk protein synthesis and SG assembly in infected host cells, which promoted intracellular bacterial proliferation.
HostingRepository	iProX
AnnounceDate	2024-01-18
AnnouncementXML	Submission_2024-05-09_20:53:46.769.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Xian
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-17 23:07:45	ID requested
1	2024-01-17 23:08:05	announced
⏵ 2	2024-05-09 20:53:47	announced	2024-05-10: Update information.

Zhang Q, Xian W, Li Z, Lu Q, Chen X, Ge J, Tang Z, Liu B, Chen Z, Gao X, Hottiger MO, Zhang P, Qiu J, Shao F, Liu X, Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex. Cell Rep, 43(2):113789(2024) [pubmed]

submitter keyword: ADP-riboxanation, stress granule

Xiaoyun Liu
contact affiliation	Peking University Health Science Center
contact email	xiaoyun.liu@bjmu.edu.cn
lab head
Wei Xian
contact affiliation	Peking University Health Science Center
contact email	xianwei@pku.edu.cn
dataset submitter

iProX dataset URI