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PXD048650

PXD048650 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMitochondrial calcium uniporter complex controls T-cell-mediated immune responses
DescriptionSustained and balanced Ca2+ increase upon T-cell receptor activation is crucial for regulation of essential T-cell functions including clonal expansion, differentiation and cytokine secretion. Thereby, mitochondria play an important role and take up Ca2+ to support elevated bioenergetic demands. The protein machinery that regulates Ca2+ flux across the inner mitochondrial membrane; the mitochondrial calcium uniporter (MCU) complex, could be thus implicated in T-cell immunity. However, the exact role of mitochondrial Ca2+, and hence, MCU in T-cells is not fully understood. Here, we provide proteomic data of downregulation of MCUa in rat CD4+ T-cells along with control T-cells.
HostingRepositoryPRIDE
AnnounceDate2024-10-23
AnnouncementXMLSubmission_2024-10-23_14:41:23.727.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGereon Poschmann
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-17 10:03:04ID requested
12024-10-23 14:41:24announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: metabolism, EAE, calcium, mitochondria, autoimmunity, T-cell,MCU
Contact List
Gereon Poschmann
contact affiliationProteome Research (AG Stühler) Institute of Molecular Medicine Heinrich Heine University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany
contact emailgereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliationMolecular Proteomics Laboratory
contact emailgereon.poschmann@hhu.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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