PXD048647

PXD048647 is an original dataset announced via ProteomeXchange.

Title	Proteomic and metabolomic signatures of rectal tumor discriminate patients with different responses to preoperative radiotherapy
Description	Background: Neoadjuvant radiotherapy (neo-RT) is widely used in locally advanced rectal cancer (LARC) as a component of radical treatment. Despite the advantages of neo-RT, which typically improves outcomes in LARC patients, the lack of reliable biomarkers that predict response and monitor the efficacy of therapy, can result in the application of unnecessary aggressive therapy affecting patients’ quality of life. Hence, the search for molecular biomarkers for assessing the radio responsiveness of this cancer represents a relevant issue. Methods: Here, we combined proteomic and metabolomic approaches to identify molecular signatures, which could discriminate LARC tumors with good and poor responses to neo-RT. Results: The integration of data on differentially accumulated proteins and metabolites made it possible to identify disrupted metabolic pathways and signaling processes connected with response to irradiation, including ketone bodies synthesis and degradation, purine metabolism, energy metabolism, degradation of fatty acid, amino acid metabolism, and focal adhesion. Moreover, we proposed multi-component panels of proteins and metabolites which could serve as a solid base to develop biomarkers for monitoring and predicting the efficacy of preoperative RT in rectal cancer patients. Conclusions: We proved that an integrated multi-omic approach presents a valid look at the analysis of the global response to cancer treatment from the perspective of metabolomic reprogramming.
HostingRepository	PRIDE
AnnounceDate	2024-05-22
AnnouncementXML	Submission_2024-05-22_12:01:36.803.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD048647
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Anna Wojakowska
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-17 08:16:08	ID requested
⏵ 1	2024-05-22 12:01:37	announced

10.3389/fonc.2024.1323961;

10.6019/PXD048647;

Wojakowska A, Marczak L, Zeman M, Chekan M, Zembala-No, ż, y, ń, ska E, Polanski K, Struga, ł, a A, Widlak P, Pietrowska M, Proteomic and metabolomic signatures of rectal tumor discriminate patients with different responses to preoperative radiotherapy. Front Oncol, 14():1323961(2024) [pubmed]

submitter keyword: tissue, proteomics, metabolomics,rectal cancer, radiotherapy

Anna Wojakowska
contact affiliation	Institute of Bioorganic Chemistry Polish Academy of Sciences
contact email	astasz@ibch.poznan.pl
lab head
Anna Wojakowska
contact affiliation	Institute of Bioorganic Chemistry Polish Academy of Sciences
contact email	astasz@ibch.poznan.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD048647

PRIDE project URI

• PRIDE
  1. PXD048647
     1. Label: PRIDE project
     2. Name: Proteomic and metabolomic signatures of rectal tumor discriminate patients with different responses to preoperative radiotherapy