PXD048640

PXD048640 is an original dataset announced via ProteomeXchange.

Title	Proteome of WT and CLPP-null Podospora Anserina
Description	Mutations in the gene for the mitochondrial matrix protease CLPP can cause human Perrault syndrome, which is characterized by male and female infertility, progressive sensorineural deafness, ataxia and leukoencephalopathy. This gene encodes a peptidase that is conserved since bacteria and localizes to mitochondrial matrix in eukaryotes. To compare and validate mouse and human findings, the filamentous fungus Podospora anserina was cultured and protein extracts were analyzed.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:46:29.417.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jana Key
SpeciesList	scientific name: Podospora anserina; NCBI TaxID: 2587412;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-17 05:09:21	ID requested
1	2024-06-22 08:33:45	announced
⏵ 2	2024-10-22 06:46:35	announced	2024-10-22: Updated project metadata.

Key J, Gispert S, Kandi AR, Heinz D, Hamann A, Osiewacz HD, Meierhofer D, Auburger G, CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation. Biomolecules, 14(2):(2024) [pubmed]

10.3390/biom14020241;

submitter keyword: CLPP, Posospora Anserina, Perrault Syndrome

Prof. Georg Auburger
contact affiliation	Experimental Neurology, University Hospital, Frankfurt am Main, Germany
contact email	auburger@em.uni-frankfurt.de
lab head
Jana Key
contact affiliation	University Hospital Frankfurt am Main
contact email	jana.key88@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD048640

PRIDE project URI

• PRIDE
  1. PXD048640
     1. Label: PRIDE project
     2. Name: Proteome of WT and CLPP-null Podospora Anserina