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PXD048640

PXD048640 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome of WT and CLPP-null Podospora Anserina
DescriptionMutations in the gene for the mitochondrial matrix protease CLPP can cause human Perrault syndrome, which is characterized by male and female infertility, progressive sensorineural deafness, ataxia and leukoencephalopathy. This gene encodes a peptidase that is conserved since bacteria and localizes to mitochondrial matrix in eukaryotes. To compare and validate mouse and human findings, the filamentous fungus Podospora anserina was cultured and protein extracts were analyzed.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:46:29.417.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJana Key
SpeciesList scientific name: Podospora anserina; NCBI TaxID: 2587412;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-17 05:09:21ID requested
12024-06-22 08:33:45announced
22024-10-22 06:46:35announced2024-10-22: Updated project metadata.
Publication List
Key J, Gispert S, Kandi AR, Heinz D, Hamann A, Osiewacz HD, Meierhofer D, Auburger G, CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation. Biomolecules, 14(2):(2024) [pubmed]
10.3390/biom14020241;
Keyword List
submitter keyword: CLPP, Posospora Anserina, Perrault Syndrome
Contact List
Prof. Georg Auburger
contact affiliationExperimental Neurology, University Hospital, Frankfurt am Main, Germany
contact emailauburger@em.uni-frankfurt.de
lab head
Jana Key
contact affiliationUniversity Hospital Frankfurt am Main
contact emailjana.key88@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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