PXD048640 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome of WT and CLPP-null Podospora Anserina |
Description | Mutations in the gene for the mitochondrial matrix protease CLPP can cause human Perrault syndrome, which is characterized by male and female infertility, progressive sensorineural deafness, ataxia and leukoencephalopathy. This gene encodes a peptidase that is conserved since bacteria and localizes to mitochondrial matrix in eukaryotes. To compare and validate mouse and human findings, the filamentous fungus Podospora anserina was cultured and protein extracts were analyzed. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:46:29.417.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jana Key |
SpeciesList | scientific name: Podospora anserina; NCBI TaxID: 2587412; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-01-17 05:09:21 | ID requested | |
1 | 2024-06-22 08:33:45 | announced | |
⏵ 2 | 2024-10-22 06:46:35 | announced | 2024-10-22: Updated project metadata. |
Publication List
Key J, Gispert S, Kandi AR, Heinz D, Hamann A, Osiewacz HD, Meierhofer D, Auburger G, CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation. Biomolecules, 14(2):(2024) [pubmed] |
10.3390/biom14020241; |
Keyword List
submitter keyword: CLPP, Posospora Anserina, Perrault Syndrome |
Contact List
Prof. Georg Auburger |
contact affiliation | Experimental Neurology, University Hospital, Frankfurt am Main, Germany |
contact email | auburger@em.uni-frankfurt.de |
lab head | |
Jana Key |
contact affiliation | University Hospital Frankfurt am Main |
contact email | jana.key88@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD048640 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048640
- Label: PRIDE project
- Name: Proteome of WT and CLPP-null Podospora Anserina