PXD048622

PXD048622 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Quantitative proteinomics on WWP2 overexpressed human tubular epithelial cells HK-2
Description	WWP2 is a E3 ligase which regulates multiple cellular events, such as stress response, differentiation. WWP2 played physiological role in the distal tubules of the kidneys. Whether WWP2 regulated pathophysiological rol in the proximal tubules is unclear. In the present study, we stably overexpressed WWP2 using lenti-viral infection in the human tubular epithelial cells, HK-2, and performed proteinomics analysis to explore WWP2's potential substrates.
HostingRepository	PRIDE
AnnounceDate	2025-06-09
AnnouncementXML	Submission_2025-06-08_16:06:05.716.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ran You
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-16 19:32:34	ID requested
⏵ 1	2025-06-08 16:06:06	announced

Publication List

You R, Li Y, Jiang Y, Hu D, Gu M, Zhou W, Zhang S, Bai M, Yang Y, Zhang Y, Huang S, Jia Z, Zhang A, WWP2 deletion aggravates acute kidney injury by targeting CDC20/autophagy axis. J Adv Res, 71():471-485(2025) [pubmed]
10.1016/j.jare.2024.06.015;

You R, Li Y, Jiang Y, Hu D, Gu M, Zhou W, Zhang S, Bai M, Yang Y, Zhang Y, Huang S, Jia Z, Zhang A, WWP2 deletion aggravates acute kidney injury by targeting CDC20/autophagy axis. J Adv Res, 71():471-485(2025) [pubmed]

10.1016/j.jare.2024.06.015;

Keyword List

submitter keyword: human tubular epithelial cells, WWP2, proteinomics

submitter keyword: human tubular epithelial cells, WWP2, proteinomics

Contact List

Aihua Zhang
contact affiliation	Children's Hospital of Nanjing Medical University
contact email	yourannch@163.com
lab head
Ran You
contact affiliation	Children's hospital of Nanjing Medical University
contact email	yourannch@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD048622
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD048622

PRIDE project URI

Repository Record List

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