PXD048617

PXD048617 is an original dataset announced via ProteomeXchange.

Title	The post-biotic sodium butyrate synergizes the antiproliferative effects of dexamethasone against the AGS gastric adenocarcinoma cell
Description	This research explores the antiproliferative effects of short-chain fatty acid (SCFA) salts (magnesium acetate, sodium propionate, and sodium butyrate) on AGS gastric adenocarcinoma cells. Sodium butyrate (NaB) exhibited the most significant inhibitory impact. The study investigated synergistic interactions between NaB and the drug dexamethasone (Dex) using a combination index model. Dex and NaB at a 2:8 ratio showed strong synergy, surpassing mono treatments in inhibitory activity. NaB induced pro-oxidative effects, countered by Dex in combination. Cell population analyses indicated a shift towards apoptosis with Dex, NaB, and their combination. Proteomic analysis revealed downregulation of the oncogene TNS4, suggesting a potential mechanism for antiproliferative effects. These findings suggest NaB as a potential adjuvant therapy with Dex, prompting further exploration of combination therapies and molecular mechanisms, emphasizing the potential application of these postbiotics in gastric cancer treatment.
HostingRepository	PRIDE
AnnounceDate	2024-02-21
AnnouncementXML	Submission_2024-02-20_21:39:18.797.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD048617
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Muhammad Alsherbiny
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-16 16:47:33	ID requested
⏵ 1	2024-02-20 21:39:19	announced

10.6019/PXD048617;

submitter keyword: Gastric cancer, proteomics,Postbiotics, sodium butyrate, dexamethasone, synergy

Deep Bhuyan
contact affiliation	NICM HRI, Western Sydney University, NSW, Australia
contact email	d.bhuyan@westernsydney.edu.au
lab head
Muhammad Alsherbiny
contact affiliation	University of New South Wales, Victor Chang Cardiac Research Institute, Western Sydney University, Cairo University
contact email	muhammad.alsherbiny@pharma.cu.edu.eg
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD048617
     1. Label: PRIDE project
     2. Name: The post-biotic sodium butyrate synergizes the antiproliferative effects of dexamethasone against the AGS gastric adenocarcinoma cell