PXD048604

PXD048604 is an original dataset announced via ProteomeXchange.

Title	Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines
Description	Daunorubicin and doxorubicin, two anthracycline polyketides produced by Streptomyces peucetius, are potent anticancer agents that are widely used in chemotherapy, despite severe side effects. Recent advances have highlighted the potential of producing improved derivatives with reduced side effects by incorporating L-rhodosamine, the N,N-dimethyl analogue of the native amino sugar moiety.
HostingRepository	PRIDE
AnnounceDate	2024-01-18
AnnouncementXML	Submission_2024-01-18_05:55:03.362.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chao DU
SpeciesList	scientific name: Streptomyces peucetius subsp. caesius; NCBI TaxID: 55158;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-16 07:14:47	ID requested
⏵ 1	2024-01-18 05:55:03	announced

Dataset with its publication pending

submitter keyword: Streptomyces peucetius, LFQ, MaxQuant, QExactive

Gilles G.P. van Wezel
contact affiliation	Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands
contact email	g.wezel@biology.leidenuniv.nl
lab head
Chao DU
contact affiliation	Leiden University
contact email	c.du@biology.leidenuniv.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD048604

PRIDE project URI

• PRIDE
  1. PXD048604
     1. Label: PRIDE project
     2. Name: Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines