PXD048473

PXD048473 is an original dataset announced via ProteomeXchange.

Title	HDX-MS Analysis of CHK2 Incubated with Calmodulin
Description	To determine the conformational dynamics upon binding of calmodulin to serine/threonine kinase CHK2.
HostingRepository	PRIDE
AnnounceDate	2025-10-15
AnnouncementXML	Submission_2025-10-15_14:19:33.671.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John Burke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	impact HD

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-11 14:07:36	ID requested
⏵ 1	2025-10-15 14:19:34	announced

Horne CR, Wang T, Young SN, Dite TA, Nyvall HG, Suresh S, Davies KA, Gonzalez Castro A, Vaibhav V, Mather J L, Dagley LF, Belousoff MJ, Manning G, Means AR, Burke JE, Petersen J, Scott JW, Murphy JM, Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity. Biochem J, ():(2025) [pubmed]

10.1042/bcj20253431;

submitter keyword: CHK2, Calmodulin, HDX-MS

Dr. John E. Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
lab head
John Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD048473

PRIDE project URI

• PRIDE
  1. PXD048473
     1. Label: PRIDE project
     2. Name: HDX-MS Analysis of CHK2 Incubated with Calmodulin