PXD048426

PXD048426 is an original dataset announced via ProteomeXchange.

Title	Phosphorylation proteomics of JEV infected microglias
Description	Japanese encephalitis virus (JEV) uses mosquitoes as the main carrier and pigs as the host. Over 60% of the world's population lives in the coverage region of JEV. Each year, 50000 to 170000 cases are reported to suffer the disease caused by JEV. The mortality rate in human is around 30%, and 50% survived patients have long-term neurological sequelae. JEV infection in pigs mainly occurs in the epidemic areas, infection with JEV can cause miscarriage and stillbirth in pigs. Infected piglets exhibit serious neurological diseases. Thus JEV poses a major risk to human and animal health. Epidemic Japanese encephalitis caused by JEV has spread in 24 countries, including Australia, Japan, India and most of the western Pacific and Southeast Asian countries. Based on the nucleotide sequences of JEV envelope protein, it can be divided into five genotypes, namely genotype I–genotype V. Genotype III was first detected in China, Genotype I has become the dominant type since it was isolated in Yunnan in 1977, then coexists with Genotype III. Understanding the distribution and prevalence of JEV genotypes have of great significance for the follow-up study, prevention and control of JEV. JEV activates the inflammatory response of microglias. Results of phosphorylation proteomics showed that proteins of cytokine-mediated signal pathway and TNF signal pathway were activated at 6 hpi. Innate immune response, apoptosis signal pathway and TLR-related pathway were all activated at 12 hpi. Defense reaction and enzyme inhibitor activity related signal pathways were activated after infection of microglias at 24 hpi.
HostingRepository	iProX
AnnounceDate	2024-01-08
AnnouncementXML	Submission_2024-01-10_18:46:32.873.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guanyu Zhao
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-10 18:46:09	ID requested
⏵ 1	2024-01-10 18:46:33	announced

Dataset with its publication pending

submitter keyword: phosphorylation proteomics, Japanese encephalitis virus, microglia

Guanyu Zhao
contact affiliation	Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences
contact email	guanyuzhao1992@163.com
lab head
Guanyu Zhao
contact affiliation	Chinese Academy of Agricultural Sciences
contact email	guanyuzhao1992@163.com
dataset submitter

iProX dataset URI