PXD048419

PXD048419 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Quantitative cell fate tracing supports the evolution of the earliest stages of ovarian cancer from mutant fallopian tube epithelial cells
Description	Ovarian cancer is also known as a silent killer as women are usually diagnosed in advanced stages when the disease has already spread to vital peritoneal organs leading to poor survival. Therefore, improving outcomes for this disease would require a greater understanding of the earliest stages, where the disease can be cured with current treatments. Fallopian tubes (FTs) are a site of origin of ovarian cancer. Here, by combining gene sequencing, proteomics, organoids, mouse genetics, lineage tracing, and quantitative modeling, we showed that mutant Pax8+ FT progenitor cells gain clonal growth advantage over their wild-type neighbors and expand over time, colonizing large areas of FT epithelium, resulting in the formation of pre-cancerous lesions. The growth of these precursor lesions is modulated by ovarian hormones, where estrogen promotes and progesterone suppresses their growth. Collectively, this study provides insight into how a single mutant FT epithelial cell leads to early ovarian cancer evolution.
HostingRepository	MassIVE
AnnounceDate	2024-01-10
AnnouncementXML	Submission_2024-01-10_17:07:44.762.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Muhammad Jamaluddin
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-10 16:51:47	ID requested
⏵ 1	2024-01-10 17:07:45	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: ovary, cancer, fallopian tube, oviduct, gynecological cancer

submitter keyword: ovary, cancer, fallopian tube, oviduct, gynecological cancer

Contact List

Muhammad Fairuz Jamaluddin
contact affiliation	University of Newcastle
contact email	muhammad.jamaluddin@newcastle.edu.au
lab head
Dr Pradeep Tanwar
contact affiliation	The University of Newcastle
contact email	pradeep.tanwar@newcastle.edu.au
lab head
Muhammad Jamaluddin
contact affiliation	University of Newcastle
contact email	muhammad.jamaluddin@newcastle.edu.au
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000093831/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000093831/