PXD048344 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comparative proteomics analysis of chorionic villi in recurrent pregnancy loss |
Description | The project aimed to determine proteomics changes in chorionic villi from patients suffering from unexplained early recurrent pregnancy loss (RPL) compared to women undergoing elective abortions. Comparative proteomics analysis by label-free data-independent LC-MS/MS was performed on fresh frozen chorionic villi from 13 RPL patients and 10 controls. Samples from EPL patients were preselected to include only patients with 2 or more recurrent pregnancy losses (RPL), no previous live birth, gestational week from 6-10 weeks and excluded fetal chromosomal abnormalities. Control samples were from women without history of previous miscarriage, ectopic pregnancy or preterm delivery, with at least one live born child, at 6-10 gestational weeks and without fetal chromosomal abnormalities. Patients and controls were between 24-44 years with no significant differences among groups regarding age (Median age RPL = 29; Median age Controls = 34; Mann–Whitney U-test p = 0.078). The mean gestational weak (GW) was 7.9±0.8 weeks in the RPL group and 8.3±1.2 weeks in the control group, without statistically significant difference between groups (Median GW RPL = 8; Median GW Controls = 8; Mann–Whitney U-test p = 0.484). |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:56:46.844.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD048344 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Katarina Davalieva |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-01-09 05:02:15 | ID requested | |
1 | 2024-08-27 10:36:29 | announced | |
⏵ 2 | 2024-10-22 06:56:47 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Human, recurrent pregnancy loss, Rapigest, Progenesis QIP, chorionic villi, biomarker, LC-MS/MS |
Contact List
Katarina Davalieva |
contact affiliation | Research Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Macedonian Academy of Sciences and Arts, Skopje, Krste Misirkov 2, 1000 Skopje, Republic of North Macedonia Tel.: +389-2-3235-410; Fax: +389-2-3115-434; |
contact email | katarina@manu.edu.mk |
lab head | |
Katarina Davalieva |
contact affiliation | Research Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Macedonian Academy of Sciences and Arts, Skopje |
contact email | katarina@manu.edu.mk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD048344 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD048344
- Label: PRIDE project
- Name: Comparative proteomics analysis of chorionic villi in recurrent pregnancy loss