PXD048344

PXD048344 is an original dataset announced via ProteomeXchange.

Title	Comparative proteomics analysis of chorionic villi in recurrent pregnancy loss
Description	The project aimed to determine proteomics changes in chorionic villi from patients suffering from unexplained early recurrent pregnancy loss (RPL) compared to women undergoing elective abortions. Comparative proteomics analysis by label-free data-independent LC-MS/MS was performed on fresh frozen chorionic villi from 13 RPL patients and 10 controls. Samples from EPL patients were preselected to include only patients with 2 or more recurrent pregnancy losses (RPL), no previous live birth, gestational week from 6-10 weeks and excluded fetal chromosomal abnormalities. Control samples were from women without history of previous miscarriage, ectopic pregnancy or preterm delivery, with at least one live born child, at 6-10 gestational weeks and without fetal chromosomal abnormalities. Patients and controls were between 24-44 years with no significant differences among groups regarding age (Median age RPL = 29; Median age Controls = 34; Mann–Whitney U-test p = 0.078). The mean gestational weak (GW) was 7.9±0.8 weeks in the RPL group and 8.3±1.2 weeks in the control group, without statistically significant difference between groups (Median GW RPL = 8; Median GW Controls = 8; Mann–Whitney U-test p = 0.484).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:56:46.844.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD048344
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Katarina Davalieva
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-09 05:02:15	ID requested
1	2024-08-27 10:36:29	announced
⏵ 2	2024-10-22 06:56:47	announced	2024-10-22: Updated project metadata.

10.1002/PRCA.202400020;

10.6019/PXD048344;

submitter keyword: Human, recurrent pregnancy loss, Rapigest, Progenesis QIP, chorionic villi, biomarker, LC-MS/MS

Katarina Davalieva
contact affiliation	Research Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Macedonian Academy of Sciences and Arts, Skopje, Krste Misirkov 2, 1000 Skopje, Republic of North Macedonia Tel.: +389-2-3235-410; Fax: +389-2-3115-434;
contact email	katarina@manu.edu.mk
lab head
Katarina Davalieva
contact affiliation	Research Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Macedonian Academy of Sciences and Arts, Skopje
contact email	katarina@manu.edu.mk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD048344

PRIDE project URI

• PRIDE
  1. PXD048344
     1. Label: PRIDE project
     2. Name: Comparative proteomics analysis of chorionic villi in recurrent pregnancy loss