PXD048331

PXD048331 is an original dataset announced via ProteomeXchange.

Title	Global analysis of protein lysine lactylation profiles in the marine bacterium Photobacterium damselae
Description	Lactylation at lysine residue (Klac) modification is a novel PTM first discovered on histones in mammalian cells in 2019 [8]. It has been observed that Klac modification on histones modulates macrophage polarization and state, and influences cellular metabolic reprogramming in pluripotent stem cells and non small cell lung cancer, and can even induce tumorigenesis [5,6]. Subsequent investigations have shown that Klac modification extends to non-histone proteins in various subcellular compartments and proteins in prokaryotic cells. To date, Klac modification has been extensively identified in various organisms, including humans [8,10-17], mice [18-20], rats [16], insects [21], plants (rice [22] and wheat [23]), fungi (Botrytis cinerea [24] and Phialophora verrucosa [25]), algae (Nannochloropsis oceanica [26]), parasites (Toxoplasma gondii [27] and Trypanosoma brucei [28]), and bacteria (Escherichia coli [5] and Streptococcus mutans [6]). These studies collectively demonstrate the evolutionary conservation of Klac modification across diverse organisms.
HostingRepository	PRIDE
AnnounceDate	2024-01-30
AnnouncementXML	Submission_2024-01-30_02:33:19.176.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xianliang Ma
SpeciesList	scientific name: Photobacterium damselae; NCBI TaxID: 38293;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-09 00:50:24	ID requested
⏵ 1	2024-01-30 02:33:19	announced

Dataset with its publication pending

submitter keyword: lysine lactylation，Photobacterium damselae，PTM

Yongxiang Yu
contact affiliation	Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academic of Fishery Sciences
contact email	maxianliangyxz@163.com
lab head
Xianliang Ma
contact affiliation	Micrometer Biotech
contact email	maxianliangyxz@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD048331

PRIDE project URI

• PRIDE
  1. PXD048331
     1. Label: PRIDE project
     2. Name: Global analysis of protein lysine lactylation profiles in the marine bacterium Photobacterium damselae