PXD048316

PXD048316 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identify the protein contents within the fluids secreted by transplanted human vascularized lung organoid
Description	We recently established a hPSC-derived 3D organoid system to mimic the vascularization process during lung differentiation. To further mature the organoid, we embedded them into the mouse kidney capsule for three months and observed the accumulation of fluid within the growing organoids. Therefore, we aim to understand if there are any proteins related to lung function are being secreted in this case.
HostingRepository	PRIDE
AnnounceDate	2025-07-06
AnnouncementXML	Submission_2025-07-06_13:36:06.576.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD048316
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Minzhe Guo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-08 08:13:16	ID requested
⏵ 1	2025-07-06 13:36:07	announced

Publication List

10.6019/PXD048316;
10.1016/j.cell.2025.05.041;
Miao Y, Pek NM, Tan C, Jiang C, Yu Z, Iwasawa K, Shi M, Kechele DO, Sundaram N, Pastrana-Gomez V, Sinner DI, Liu X, Lin KC, Na CL, Kishimoto K, Yang MC, Maharjan S, Tchieu J, Whitsett JA, Zhang YS, McCracken KW, Rottier RJ, Kotton DN, Helmrath MA, Wells JM, Takebe T, Zorn AM, Chen YW, Guo M, Gu M, Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids. Cell, ():(2025) [pubmed]

10.6019/PXD048316;

10.1016/j.cell.2025.05.041;

Miao Y, Pek NM, Tan C, Jiang C, Yu Z, Iwasawa K, Shi M, Kechele DO, Sundaram N, Pastrana-Gomez V, Sinner DI, Liu X, Lin KC, Na CL, Kishimoto K, Yang MC, Maharjan S, Tchieu J, Whitsett JA, Zhang YS, McCracken KW, Rottier RJ, Kotton DN, Helmrath MA, Wells JM, Takebe T, Zorn AM, Chen YW, Guo M, Gu M, Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids. Cell, ():(2025) [pubmed]

Keyword List

submitter keyword: transplantation, vasculature, lung,Organoid

submitter keyword: transplantation, vasculature, lung,Organoid

Contact List

Mingxia Gu
contact affiliation	Divisions of Pulmonary Biology, Molecular Cardiovascular Biology and Developmental Biology Department of Pediatrics Cincinnati Children's Hospital Medical Center Cincinnati, OH 45229
contact email	mingxia.gu@cchmc.org
lab head
Minzhe Guo
contact affiliation	Cincinnati Children's Hospital Medical Center
contact email	minzhe.guo@cchmc.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD048316
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD048316

PRIDE project URI

Repository Record List

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