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PXD048273

PXD048273 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChemical mixture effects on the simplified human intestinal microbiota (SIHUMIx): Assessing Bisphenols and PFAS at environmentally realistic concentrations
DescriptionThe gut microbiota in our intestinal tract metabolizes non-digestible compounds into essential nutrients and signaling molecules (i.e. short-chain fatty acids), affecting our immune system and the development of various human diseases. Ingested environmental contaminants (xenobiotics) can disrupt the bacterial community and enzymatic activity, ultimately influencing the host. Pervasive xenobiotics include bisphenols and poly- and perfluoroalkyl substances (PFAS). Both classes of chemicals have been reported to affect the immune system and cause adverse effects on human metabolism. Since humans are exposed to a complex mixture of environmental contaminants it is critical to evaluate the effects of xenobiotics in mixtures. In our study, an in vitro bioreactor model system based on the simplified human microbiome model (SIHUMIx) was used to investigate the direct effects of either perfluorooctanoic acid (PFOA), perfluorohexanoic acid (PFHxA) and perfluorobutanoic acid (PFBA) or bisphenol S (BPS) and bisphenol F (BPF) or a combined mixture on the microbiota. We observed an increased production of the short-chain fatty acids (SCFAs) acetate and butyrate following PFAS exposure. A metaproteomics approach revealed changes in molecular pathways in all treatments, including alterations in vitamin and cofactor synthesis and an additional effect on fatty acid synthesis in BPX-treated reactors. This study highlights the need to assess the combined effects of xenobiotics and to better protect public health by considering adverse effects on the microbiome in the risk assessment of environmental chemicals.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:44:53.085.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNico Jehmlich
SpeciesList scientific name: Erysipelatoclostridium ramosum DSM 1402; NCBI TaxID: 445974; scientific name: Bifidobacterium longum subsp. longum; NCBI TaxID: 1679; scientific name: Clostridium butyricum DSM 10702; NCBI TaxID: 1316931; scientific name: Escherichia coli str. K-12 substr. MG1655; NCBI TaxID: 511145; scientific name: Blautia producta ATCC 27340 = DSM 2950; NCBI TaxID: 1121114; scientific name: Anaerostipes caccae; NCBI TaxID: 105841; scientific name: Bacteroides thetaiotaomicron; NCBI TaxID: 818; scientific name: Lactobacillus plantarum subsp. plantarum; NCBI TaxID: 337330;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-01-05 03:29:15ID requested
12024-06-13 08:19:57announced
22024-10-22 06:44:53announced2024-10-22: Updated project metadata.
Publication List
10.1016/J.JHAZMAT.2024.134683;
Keyword List
submitter keyword: SCFA, continuous bioreactor model system, bisphenols, gut microbiota,PFAS, microbiome-dependent toxicity, metaproteomics
Contact List
Nico Jehmlich
contact affiliationHelmholtz-Centrte for Environmental Research - UFZ GmbH Department of Molecular Systems Biology Permoserstr. 15 04318 Leipzig, Germany
contact emailnico.jehmlich@ufz.de
lab head
Nico Jehmlich
contact affiliationHelmholtz-Centre for Environmental Research - UFZ
contact emailnico.jehmlich@ufz.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
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