PXD048262

PXD048262 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	WEHI991 drug target identification by DIA Solvent PISA
Description	Here we demonstrate PfSTART1 engagement by WEHI991 in the P. falciparum proteome using organic solvent-based Proteome Integral Solubility Alteration (Solvent PISA) assay coupled with Data Independent Acquisition Mass Spectrometry (DIA-MS).
HostingRepository	jPOST
AnnounceDate	2024-05-01
AnnouncementXML	Submission_2025-10-20_16:14:35.750.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jerzy Michal Dziekan
SpeciesList	scientific name: Plasmodium (Plasmodium); NCBI TaxID: 418103;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-04 18:07:15	ID requested
1	2024-05-01 04:12:54	announced
⏵ 2	2025-10-20 16:14:36	announced	2025-10-21: Updated PubMed.

Publication List

Dans MG, Boulet C, Watson GM, Nguyen W, Dziekan JM, Evelyn C, Reaksudsan K, Mehra S, Razook Z, Geoghegan ND, Mlodzianoski MJ, Goodman CD, Ling DB, Jonsdottir TK, Tong J, Famodimu MT, Kristan M, Pollard H, Stewart LB, Brandner-Garrod L, Sutherland CJ, Delves MJ, McFadden GI, Barry AE, Crabb BS, de Koning-Ward TF, Rogers KL, Cowman AF, Tham WH, Sleebs BE, Gilson PR, Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1. Nat Commun, 15(1):5219(2024) [pubmed]

Dans MG, Boulet C, Watson GM, Nguyen W, Dziekan JM, Evelyn C, Reaksudsan K, Mehra S, Razook Z, Geoghegan ND, Mlodzianoski MJ, Goodman CD, Ling DB, Jonsdottir TK, Tong J, Famodimu MT, Kristan M, Pollard H, Stewart LB, Brandner-Garrod L, Sutherland CJ, Delves MJ, McFadden GI, Barry AE, Crabb BS, de Koning-Ward TF, Rogers KL, Cowman AF, Tham WH, Sleebs BE, Gilson PR, Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1. Nat Commun, 15(1):5219(2024) [pubmed]

Keyword List

submitter keyword: PISA, SPP, SIP, Target ID, WEHI991, Solvent Proteome Profiling, Plasmodium

submitter keyword: PISA, SPP, SIP, Target ID, WEHI991, Solvent Proteome Profiling, Plasmodium

Contact List

Jerzy Dziekan
lab head
Jerzy Michal Dziekan
contact affiliation	The Walter and Eliza Hall Institute of Medical Research
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002439/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002439/