PXD048106
PXD048106 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | CD9-dependent extracellular vesicles mediate the propagation of ferroptosis |
Description | Cells generate mass amount of EVs during ferroptosis. To evaluate the unique proteins secreted by ferroptitic EVs, and the potential mechnism of ferroptosis propagation through EV transportation,we analysed the proteomics of EVs from U-2 OS cells. U-2 OS cells were treated with DMSO or RSL3 (to induce ferroptosis) and EVs were collected from the culture medium.We further evaluated teh mice kidney derived EV proteomics and identified upregulated proteins in RSL3-treated mice. To elucidate the function of CD9-positive EVs, we generated wild type and CD9-KO HT1080 xenografts and treated the mice with RSL3 and enriched the xenograft EVs and performed proteomics analysis. |
HostingRepository | iProX |
AnnounceDate | 2023-12-24 |
AnnouncementXML | Submission_2023-12-24_20:03:59.216.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tianyu Guo |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-12-24 20:03:28 | ID requested | |
⏵ 1 | 2023-12-24 20:03:59 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: ferroptosis, extracellular vesicles |
Contact List
Hai Huang | |
---|---|
contact affiliation | Zhejiang University |
contact email | haihuang@zju.edu.cn |
lab head | |
Tianyu Guo | |
contact affiliation | Zhejiang University |
contact email | 0620197@zju.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |