PXD048074

PXD048074 is an original dataset announced via ProteomeXchange.

Title	Surface Proteome of Extracellular Vesicles and Correlation Analysis for Identification of Breast Cancer Biomarkers
Description	Breast cancer (BC) is the second leading cause of death in Canadian women. Despite this, non-invasive early detection methods for BC have yet to be developed. Cells release various types of extracellular vesicles (EVs) as intercellular signals into biofluids, such as blood, reflecting the physiological state of the origin cell. It is by transmitting bioactive molecules between cells that EVs may regulate multiple pathologies in human diseases, including cancer. The detection of protein biomarkers present on the surface of EVs in depleted or enriched biofluids could enable the early diagnosis of BC. Therefore, we used two different approaches to study the surfactome of EVs from cancerous and non-cancerous cells. We found several potential biomarkers that may be involved in the early diagnosis of BC.
HostingRepository	PRIDE
AnnounceDate	2024-05-21
AnnouncementXML	Submission_2024-05-21_10:21:29.174.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nico Hüttmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-22 01:36:50	ID requested
⏵ 1	2024-05-21 10:21:30	announced

H, ü, ttmann N, Li Y, Poolsup S, Zaripov E, D'Mello R, Susevski V, Minic Z, Berezovski MV, Surface Proteome of Extracellular Vesicles and Correlation Analysis Reveal Breast Cancer Biomarkers. Cancers (Basel), 16(3):(2024) [pubmed]

10.3390/cancers16030520;

submitter keyword: Surface proteins,Breast cancer, Proteomics, Biomarkers, Extracellular vesicles

Maxim Valentinovich Berezovski
contact affiliation	Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada
contact email	Maxim.Berezovski@uOttawa.ca
lab head
Nico Hüttmann
contact affiliation	John L. Holmes Mass Spectrometry Facility, Faculty of Science, University of Ottawa, Canada
contact email	nhutt069@uottawa.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD048074

PRIDE project URI

• PRIDE
  1. PXD048074
     1. Label: PRIDE project
     2. Name: Surface Proteome of Extracellular Vesicles and Correlation Analysis for Identification of Breast Cancer Biomarkers