PXD048062

PXD048062 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Immunoprecipitated PTPN22 Phosphoproteomics from Jurkat Cells
Description	3x FLAG tagged PTPN22 were immunoprecipitated from Jurkat cells stimulated by TCR for 5min, and the proteins were eluted by FLAG peptides. This study aims to explore the phosphorylation sites on PTPN22 phosphatase, identifying two phosphorylation sites Ser325 and Ser449.
HostingRepository	MassIVE
AnnounceDate	2024-12-03
AnnouncementXML	Submission_2024-12-03_15:46:45.945.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Leigh-Ana Rossitto
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Phospho; Carbamidomethyl; Oxidation
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-12-21 18:24:08	ID requested
⏵ 1	2024-12-03 15:46:46	announced

Publication List

Zhuang C, Yang S, Gonzalez CG, Ainsworth RI, Li S, Kobayashi MT, Wierzbicki I, Rossitto LM, Wen Y, Peti W, Stanford SM, Gonzalez DJ, Murali R, Santelli E, Bottini N, A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. J Biol Chem, 300(6):107393(2024) [pubmed]

Zhuang C, Yang S, Gonzalez CG, Ainsworth RI, Li S, Kobayashi MT, Wierzbicki I, Rossitto LM, Wen Y, Peti W, Stanford SM, Gonzalez DJ, Murali R, Santelli E, Bottini N, A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. J Biol Chem, 300(6):107393(2024) [pubmed]

Keyword List

submitter keyword: PTPN22, Protein tyrosine kinases, Protein tyrosine phosphatases, T cell signaling, IP-MS

submitter keyword: PTPN22, Protein tyrosine kinases, Protein tyrosine phosphatases, T cell signaling, IP-MS

Contact List

Nunzio Bottini
contact affiliation	ACTRI
contact email	nbottini@ucsd.edu
lab head
David J Gonzalez
contact affiliation	UCSD
contact email	djgonzalez@health.ucsd.edu
lab head
Leigh-Ana Rossitto
contact affiliation	UCSD
contact email	lrossitt@health.ucsd.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v06/MSV000093717/